Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 101-110 of 1,773 results
Cell Mol Neurobiol, 2013 • July 28, 2013
This study aimed to determine if Wnt signaling-activated olfactory ensheathing cells (wOECs) can promote synaptogenesis and neurite growth in vitro, comparing them to control OECs and Wnt-inhibited OE...
KEY FINDING: Wnt-activated OECs (wOECs CM) exhibited a stronger axonal growth-promoting effect than control OECs CM (cOECs CM).
Neurosci Bull, 2013 • August 1, 2013
Membrane disruption has serious downstream structural and functional consequences in the mechanical injury of neuronal tissue. PEG-mediated resealing of cell membranes is a practical method to repair ...
KEY FINDING: Polyethylene glycol (PEG) can reseal axonal membranes following various injuries in multiple in vitro and in vivo injury models.
Trends Genet, 2013 • November 1, 2013
Zebrafish are a key genetic model system for vertebrate regeneration research. Toolsets continue to evolve for studies of zebrafish appendage, heart, and neural regeneration. Regeneration concepts and...
KEY FINDING: Differentiated osteoblasts transiently downregulate the osteogenic program, or dedifferentiate, as they contribute to the blastema. After this, resident osteoblasts contribute only osteoblasts to new regenerated structures
PLoS ONE, 2013 • July 23, 2013
This study demonstrates that P45, a member of the death domain superfamily, interacts with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation ...
KEY FINDING: P45 forms a complex with FADD, and the DED domain of FADD is required for this interaction.
PLoS ONE, 2013 • August 12, 2013
The study investigated spinal cord injuries in developing opossums at postnatal days 7 and 28 to understand neuronal circuit remodeling and locomotor recovery. P7-injured opossums showed axonal regrow...
KEY FINDING: P7-injured animals regrew supraspinal and propriospinal axons through the injury site and recovered near-normal coordinated overground locomotion with altered gait characteristics.
PLoS ONE, 2013 • August 12, 2013
The study explores the interaction between carbon nanotube scaffolds and immature spinal cord neurons in vitro. The central finding is that spinal neurons adherent to carbon nanotube substrates underg...
KEY FINDING: Spinal neurons cultured on carbon nanotubes exhibit a 37% reduction in membrane capacitance, suggesting a difference in soma size and/or neurite extension.
Stem Cell Reports, 2013 • June 4, 2013
This study introduces a comprehensive set of germline transgenic strains in the laboratory-bred salamander Ambystoma mexicanum (axolotl) that open up the cellular and molecular genetic dissection of r...
KEY FINDING: The study successfully established germline transgenic axolotl strains showing faithful, cell-type-specific expression of EGFP gene using tissue-specific promoters from different animal species.
PLoS ONE, 2013 • September 10, 2013
This study identifies SOCS1 as a novel target gene of the Hh/GLI signaling pathway in epidermal and neural tumor cells. The Hh/GLI pathway, when activated, upregulates SOCS1 expression. Upregulation o...
KEY FINDING: SOCS1 is identified as a direct transcriptional target of Hh/GLI signaling in human keratinocytes and medulloblastoma cells.
JOURNAL OF NEUROTRAUMA, 2014 • March 15, 2014
The study demonstrates the feasibility of using a regulatable L1 expression system in human embryonic stem cell-derived neural stem cells (H9NSCs) to improve cell-based therapy for spinal cord injury ...
KEY FINDING: Regulatable L1 expression system: The study successfully developed a nonviral doxycycline-inducible system to control L1 expression in human neural stem cells (H9NSCs).
Dev Neurobiol, 2014 • August 1, 2014
This study examined the expression patterns and levels of aPKC and Ryk in the lumbar spinal cord of SOD1 (G93A) mice, a model of ALS. The researchers found that aPKC was upregulated in motor neurons a...
KEY FINDING: aPKC expression was increased in motor neurons of the lumbar spinal cord in SOD1 (G93A) mice at different stages, and colocalized with SOD1 in motor neuron cell bodies and extracellular aggregates.