Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 111-120 of 1,773 results
BioMed Research International, 2013 • August 7, 2013
This review discusses the supportive roles of various ECM molecules in neurite outgrowth, while acknowledging that ECM molecules also impact synapse formation and neural stem cell migration. Novel dev...
KEY FINDING: Laminins promote axonal growth in both the developing and adult nervous systems, particularly in areas where regeneration occurs.
BMC Neuroscience, 2013 • November 13, 2013
This study investigates the differential properties of canine olfactory ensheathing cells (OECs) from the olfactory bulb (OB-OECs) and mucosa (OM-OECs) compared to Schwann cells, focusing on their mig...
KEY FINDING: OB-OECs migrate significantly faster than OM-OECs and Schwann cells in a scratch wound assay.
PLoS ONE, 2013 • November 1, 2013
The study investigates the role of GFAP and vimentin in nerve regeneration and synaptic stripping after sciatic nerve lesion in mice. Results showed reduced synaptic elimination, delayed reinnervation...
KEY FINDING: GFAP–/–Vim–/– mice showed less removal of synaptic boutons from injured motoneurons compared to wild-type mice after axotomy.
Immunology, 2014 • February 1, 2014
Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor dysfunction. The growing awareness that the immune sys...
KEY FINDING: Chronic activation of innate immune responses, especially by microglia, is a common link among various neurodegenerative diseases, potentially leading to neurotoxic pathways and progressive degeneration.
The Journal of Neuroscience, 2013 • December 11, 2013
The study establishes a correlation between diminished axon growth potential and histone 4 (H4) hypoacetylation in mature dorsal root ganglion (DRG) neurons. It identifies a transcriptional complex in...
KEY FINDING: Diminished axon growth potential correlates with histone 4 (H4) hypoacetylation in mature DRG neurons.
Front Biol (Beijing), 2013 • August 1, 2013
Brain and spinal cord injuries initiate widespread temporal and spatial neurodegeneration, through both necrotic and programmed cell death mechanisms. Successful treatments rely on prevention or reduc...
KEY FINDING: Downregulating PTEN promotes axon regeneration and neuroprotection following CNS trauma.
Journal of Clinical and Diagnostic Research, 2013 • November 10, 2013
This study focused on isolating Globose Basal Cells (GBCs) from the olfactory mucosa of Albino Wistar rats, as these cells possess the ability to regenerate olfactory mucosa throughout life. The chall...
KEY FINDING: The study standardized techniques for isolating GBCs from rat olfactory mucosa using GBC-III antibody and FACS.
PLoS ONE, 2014 • January 3, 2014
This study investigates the role of ADAM10 in spinal cord development, finding that its downregulation leads to precocious neuronal differentiation. The mechanism involves ADAM10's metalloprotease dom...
KEY FINDING: Downregulation of ADAM10 drives precocious differentiation of neural progenitor cells and radial glial cells, resulting in an increase of neurons in the developing spinal cord.
PLoS ONE, 2014 • February 3, 2014
This study introduces the use of self-complementary adeno-associated virus serotype 2 (scAAV2) as an effective tracer for labeling axons, demonstrating its ability to efficiently transduce neurons and...
KEY FINDING: scAAV2-GFP efficiently transduces neurons in the sensorimotor cortex, red nucleus, and DRG, with strong GFP expression transported anterogradely along axons to label numerous axon fibers from CST, RST, and central axons of DRG.
Journal of Anatomy, 2014 • February 7, 2014
This study examined the role of c-Jun activation in neonatal rat motoneurons after nerve crush injury, observing both degeneration and regeneration. The key finding was that all injured motoneurons in...
KEY FINDING: Nerve crush injury in neonatal rats leads to two distinct outcomes for motoneurons: approximately 60% undergo degeneration, while 40% survive and regenerate.