Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 91-100 of 1,773 results
Brain, 2013 • July 1, 2013
This study investigates the role of neuregulin 1 (NRG1) in nerve repair following injury in adult mice by conditionally ablating NRG1. The researchers found that NRG1 is not required for maintaining t...
KEY FINDING: Loss of neuregulin 1 impairs remyelination after nerve crush, but does not affect Schwann cell proliferation associated with Wallerian degeneration or axon regeneration or the clearance of myelin debris by macrophages.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
The study analyzes mRNA expression levels of p75NTR, Trk A, and caspase-9 in a rat model of spinal cord injury (SCI) at different time points and locations around the injury site. Results show a compl...
KEY FINDING: The expression of p75NTR, Trk A, and caspase-9 mRNA changes after SCI, with the greatest variation observed in the center regions of the injury.
Cerebral Cortex, 2014 • June 28, 2013
The study demonstrates that direct cortical delivery of the PKC inhibitor GÖ6976 promotes CST axonal regeneration and enhances forelimb functional recovery in rats with cervical spinal cord injuries. ...
KEY FINDING: Cortical delivery of GÖ6976 reduced injury-induced activation of conventional PKCα and PKCβ1 in CST neurons.
Glia, 2013 • September 1, 2013
The study aimed to identify novel regulators of glial development using Aldh1l1-GFP as a marker for gliogenic radial glia and later-stage precursors of developing astrocytes. Gene expression profiling...
KEY FINDING: Aldh1l1 is a useful marker for identifying gliogenic lineages during embryonic spinal cord development.
PLoS ONE, 2013 • July 3, 2013
This study uses a genetic approach to understand the variation in tail regeneration among salamanders. A hybrid population of Ambystoma salamanders was studied to identify genetic and morphological fa...
KEY FINDING: Tail width at the amputation plane largely determines the rate of regenerative outgrowth in salamanders.
Neurosci Bull, 2013 • August 1, 2013
Successful axonal regeneration in the injured nervous system is a complex process that involves coordinated regulation of gene expression in the soma and cytoskeleton assembly at the growth cone. The ...
KEY FINDING: A large-scale RNAi-based genetic screen has identified dual leucine zipper-bearing kinase 1 (DLK-1) as a key regulator of axon regeneration
STEM CELLS TRANSLATIONAL MEDICINE, 2013 • August 9, 2013
The study investigates enhancing tissue regeneration using progenitor cell-based therapy, addressing the primary barrier of the hostile environment that progenitor cells encounter in clinical injury w...
KEY FINDING: Overexpression of Bcl-2 in hASCs decreases mediators of apoptosis in vitro and in vivo.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • September 13, 2013
This study identifies a novel mechanism for promoting axonal sprouting and regeneration in the CNS in vivo: the targeting of LRP1 receptors. Agonists of this LDL gene family receptor result in activat...
KEY FINDING: LRP1 activation promotes neurite outgrowth from adult DRG sensory neurons under both permissive and non-permissive conditions.
Exp Eye Res, 2014 • June 1, 2014
This article reviews the mechanisms involved in neuronal regeneration in the adult zebrafish retina, focusing on the role of Müller glia. Retinal damage induces Müller glia to dedifferentiate and reen...
KEY FINDING: TNFα, a signaling molecule, is produced by dying retinal neurons and signals to Müller glia to initiate proliferation. Knockdown of TNFα expression significantly reduced Müller glial proliferation.
Molecular Therapy—Nucleic Acids, 2013 • July 23, 2013
The study demonstrates that AAV can be retrogradely transported by axons severed by SCI to transduce supraspinal neurons. Intraspinal injection of AAV near the injury site resulted in transduction of ...
KEY FINDING: AAV injected into the spinal cord near an injury site can travel to the brain and deliver genes to nerve cells.