Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,061-1,070 of 1,773 results
Not specified, 2023 • January 9, 2023
This study investigates the role of macrophages in astrocyte migration following spinal cord injury (SCI). It demonstrates that macrophages attract astrocytes to the injury site, influencing glial sca...
KEY FINDING: Impaired macrophage migration leads to a more widespread distribution of astrocytes and an increased scar area after spinal cord injury.
Curr. Issues Mol. Biol., 2023 • February 16, 2023
This study investigates the molecular effects of hypoxic stress on neuronal cells chronically exposed to ethanol, using in vitro models to mimic spinal cord injury conditions in alcohol-consuming pati...
KEY FINDING: Long-term ethanol exposure has a cytotoxic effect on neuronal cells, inducing apoptosis.
Cell Prolif., 2023 • September 1, 2023
This study profiles the transcriptomes, nucleosome positioning, and histone modifications of mouse haESC lines, comparing these profiles with those of other closely-related stem cell lines, MII oocyte...
KEY FINDING: haESCs exhibit transcriptome profiles more similar to those of naïve pluripotent stem cells, with repressed Xist indicating no X chromosome inactivation.
bioRxiv, 2023 • February 27, 2023
This study investigates the role of DOCK3 in skeletal muscle using a muscle-specific knockout mouse model. The researchers found that loss of DOCK3 in skeletal muscle leads to impaired muscle regenera...
KEY FINDING: Dock3 mKO mice presented with significant hyperglycemia and increased fat mass, indicating a metabolic role in the maintenance of skeletal muscle health.
Nature Communications, 2023 • March 3, 2023
This study elucidates how histone H2A monoubiquitination (H2Aub1) is targeted to specific genomic locations in Arabidopsis by cohesin subunits. The findings demonstrate that AtSYN4 interacts with AtSC...
KEY FINDING: The Arabidopsis cohesin subunits AtSYN4 and AtSCC3 interact with each other, and AtSCC3 binds to AtBMI1s.
Burns & Trauma, 2023 • January 1, 2023
Inflammation has a complex role in SCI, with early events critical for clearing debris and limiting acute injury severity. Excessive inflammation after acute stages can impair regeneration, but certai...
KEY FINDING: Inflammatory responses after SCI are complex, with both beneficial and detrimental effects.
iScience, 2023 • March 17, 2023
The study found that glutaminase gene activity is required for optimal C. elegans sperm function. Tissue-specific gene manipulations showed that germline glutaminase activity plays an important role. ...
KEY FINDING: Glutaminase gene activity is required for optimal sperm function in C. elegans.
Journal of Orthopaedic Translation, 2023 • February 6, 2023
This study investigates the therapeutic potential of cerebrospinal fluid-derived extracellular vesicles (CSF-EVs) for spinal cord injury (SCI). The researchers isolated CSF-EVs from pigs with SCI and ...
KEY FINDING: CSF-EVs, especially those derived from pigs with SCI (SCI-EVs), promote vascular regeneration more effectively than those from pigs without SCI (Sham-EVs).
The Journal of Spinal Cord Medicine, 2024 • February 28, 2023
This study investigated the neuroprotective effects of PCA on SCI in rats, focusing on the Wnt/β-catenin pathway. The results showed that PCA activated the Wnt/β-catenin signaling pathway, leading to ...
KEY FINDING: PCA treatment activates the Wnt/β-catenin signaling axis in vivo and in vitro.
Bioscience Reports, 2023 • April 6, 2023
This study investigates the role of miR-6315 in spinal cord injury (SCI) in rats, finding it significantly upregulated after SCI. Bioinformatics analysis predicted a targeting relation between miR-631...
KEY FINDING: miR-6315 was significantly up-regulated and differentially expressed miRNA after 24 h of SCI.