Protocatechuic aldehyde promotes the functional recovery of spinal cord injury by activating the Wnt/β-catenin signaling pathway

This study explores how a substance called protocatechuic aldehyde (PCA) can help rats recover from spinal cord injuries (SCI). It investigates PCA's ability to reduce inflammation and protect nerve cells after such injuries. The research focuses on the Wnt/β-catenin pathway, which is important for cell growth and nerve cell function. The study looks at how PCA affects this pathway in SCI. The findings suggest that PCA can reduce inflammation and prevent nerve cell death by activating the Wnt/β-catenin pathway, leading to better recovery from SCI.

• 1
  PCA treatment activates the Wnt/β-catenin signaling axis in vivo and in vitro.
• 2
  PCA improves tissue protection and functional recovery after SCI through the Wnt/β-catenin axis.
• 3
  PCA inhibits neuronal apoptosis in the spinal cord and LPS-induced microglial cell death.