Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,051-1,060 of 1,773 results
The Journal of Neuroscience, 2023 • March 1, 2023
This study investigates the role of m6A modification in spinal cord injury (SCI), revealing that METTL3, a core subunit of methyltransferase complex, is upregulated in reactive astrocytes and stabiliz...
KEY FINDING: METTL3 is upregulated in reactive astrocytes after SCI and stabilized by the USP1/UAF1 complex, which removes K48-linked ubiquitination of METTL3.
Int. J. Mol. Sci., 2023 • January 12, 2023
This study investigates the potential of using chondrocytes isolated from loose bodies (LB-CH) as a cell source for autologous chondrocyte implantation (ACI) to reduce donor site morbidity. LB-CH were...
KEY FINDING: LB-CH exhibited comparable viability and proliferation rates to control cells during long-term expansion, with no ultimate cell cycle arrest observed within 12 passages.
Life, 2023 • December 20, 2022
Traumatic SCI induces complex pathological processes, leading to physical impairment and psychological devastation. The two phases are primary mechanical damage and secondary injury. This involves vas...
KEY FINDING: Neurotrophic factors like NGF, BDNF, and NT-3 are involved in the nervous system's development and maintenance, helping to rebalance the microenvironment after SCI. Mature NGF is neuroprotective, promoting neuronal differentiation and survival. BDNF has neuroprotective and growth-promoting effects, promoting regeneration and formation of damaged axons.
Oxidative Medicine and Cellular Longevity, 2023 • January 12, 2023
This study aimed to identify specific molecular mechanisms in acute SCI patients compared to trauma controls by analyzing RNA-seq datasets and identifying differentially expressed genes (DEGs). The an...
KEY FINDING: A total of 64 specific genes were identified as the intersection of upregulated genes of the spinal cord and upregulated genes of human blood samples in SCI patients compared to trauma controls.
中国修复重建外科杂志, 2023 • January 1, 2023
This study investigates the neuroprotective effects of TGTP hydrogel on spinal cord injury in rats. The results demonstrate that TGTP hydrogel effectively promotes motor function recovery, improves my...
KEY FINDING: TGTP hydrogel significantly improved BBB scores in rats with spinal cord injuries compared to the model group, indicating better motor function recovery.
Frontiers in Pharmacology, 2023 • January 16, 2023
This research investigates the neuroregenerative potential of Fraction B (FB) derived from catfish epidermal secretions in a rat model of sciatic nerve crush injury. The study demonstrates that FB trea...
KEY FINDING: FB treatment improved motor and sensory functions after sciatic nerve crush injury, as evidenced by improved performance in tests like foot positioning, toe spread, and thermal hyperalgesia.
Open Medicine, 2023 • January 1, 2023
This study investigates the role of TERC in spinal cord injury (SCI) using rat models and LPS-induced PC-12 cells. The findings reveal that TERC is upregulated in SCI tissues and cells, contributing t...
KEY FINDING: TERC knockdown alleviated histopathological abnormalities in SCI tissues and promoted cell viability, migration, and invasion while inhibiting apoptosis in LPS-induced PC-12 cells.
Neurochemical Research, 2023 • February 7, 2023
This study explored the effect and mechanism of miR-155-5p on astrocyte activation and glial scarring in a spinal cord injury (SCI) model. The findings indicated that miR-155-5p overexpression aggrava...
KEY FINDING: MiR-155-5p overexpression promotes astrocyte proliferation, invasion, and inhibits apoptosis in vitro, suggesting its role in astrocyte activation.
Communications Biology, 2023 • February 23, 2023
This study presents a refined method for generating human iPSC-derived retinal sheets, incorporating a quality control strategy and a novel preservation technique for tissue-transplantation therapy. T...
KEY FINDING: A qPCR-based quality control method was developed, allowing for selection of retinal tissue sheets suitable for transplantation.
Cell Transplantation, 2023 • January 16, 2023
This study explored the role and molecular mechanism of human menstrual blood–derived endometrial stem cells (MenSCs) in spinal cord injury (SCI) using a mouse model. The results showed that MenSC tra...
KEY FINDING: MenSCs significantly improved locomotor function in SCI mice.