Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,011-1,020 of 1,773 results
PLoS Biology, 2022 • September 20, 2022
The study investigates the potential of CBP/p300 activation to promote neurological recovery in chronic SCI with severe disability using the CBP/p300 activator CSP-TTK21 in mice. CSP-TTK21 enhanced re...
KEY FINDING: CSP-TTK21 enhanced classical regenerative signalling in dorsal root ganglia sensory neurons but not cortical motor neurons.
Nucleic Acids Research, 2022 • September 26, 2022
The study introduces SCRIP, a computational method for inferring single-cell gene regulation networks by integrating scATAC-seq data with a large-scale ChIP-seq reference. SCRIP evaluates TR activity ...
KEY FINDING: SCRIP shows improved performance in evaluating TR binding activity compared to motif-based methods, with higher consistency with matched TR expressions.
Frontiers in Neuroscience, 2022 • September 8, 2022
This mini-review discusses the roles of DYRK2 in neuronal morphogenesis, nervous system development, and nervous system diseases. DYRK2 plays a key role in regulating the cytoskeleton, influencing neu...
KEY FINDING: DYRK2 regulates neuronal morphogenesis (e.g., axon growth and branching) by phosphorylating cytoskeletal elements (e.g., doublecortin).
Inflammation and Regeneration, 2022 • September 2, 2022
This study investigates the mechanism of pericyte-fibroblast transition after spinal cord injury (SCI) and the role of the PDGF-BB/PDGFRβ signaling pathway in this process. The results show that micro...
KEY FINDING: PDGFRβ+ pericytes detach from blood vessel walls and transition into fibroblasts to form fibrotic scar after SCI, indicating a key role in scar formation.
npj Genomic Medicine, 2022 • August 8, 2022
Based on TCGA and TCGASpliceSeq databases, gene expression and the AS data of UCEC samples were retrieved. These findings indicate that HSPB1, a splicing factor, regulates the expression of ANKHD1-BP3 ...
KEY FINDING: An alternate terminator of ANKHD1 transcripts named ANKHD1-BP3 was found to be significantly related to metastasis and OS in UCEC and significantly associated with HSPB1.
Frontiers in Neuroscience, 2022 • September 20, 2022
This review challenges the traditional view of astrocytes as inhibitors of axon regeneration in the injured CNS, highlighting evidence that supports their positive role in axon growth. Astrocytes' cap...
KEY FINDING: Astrocytes can support axon regeneration under experimental conditions that enhance axons’ intrinsic capacity to grow, such as through Pten gene deletion.
Frontiers in Cellular Neuroscience, 2022 • September 23, 2022
This review discusses the current research on m6A modification and its relationship with pathophysiological processes after SCI, including cell death, axonal regeneration, and scarring. Research on th...
KEY FINDING: m6A modification levels change after spinal cord injury (SCI), and m6A-related regulators are involved in the changes of the local spinal cord microenvironment after injury.
Int. J. Mol. Sci., 2022 • September 26, 2022
This review discusses the potential connection between ALS-related genes/proteins and neuroregeneration and development, particularly focusing on the timing when neuroregeneration ceases. The authors ...
KEY FINDING: Fifteen risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS.
Neural Regeneration Research, 2023 • May 1, 2023
This review provides an overview of vimentin's role in various nervous system injuries and diseases, including spinal cord injury, stroke, bacterial meningitis, gliomas, and peripheral nerve injury. V...
KEY FINDING: In spinal cord injury, vimentin and GFAP knockout mice show reduced glial scar and improved motor function, but in stroke, attenuated glial scar leads to worse neurological recovery.
Cell Regeneration, 2022 • January 1, 2022
Recent studies using advanced single-cell-omics techniques have mapped the cellular diversity and dynamics during brain development and regeneration in salamanders, providing a foundation for understa...
KEY FINDING: The neuronal diversity in the salamander brain is unexpectedly high, with studies identifying numerous clusters of glutamatergic and GABAergic neurons, suggesting a greater complexity than previously thought.