Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,001-1,010 of 1,773 results
Journal of Nanobiotechnology, 2022 • January 1, 2022
This study demonstrates the novel function of Gel-Exo in promoting behavioural and electrophysiological performance in mice with SCI. RNA-seq results indicated that Vgf (nerve growth factor inducible)...
KEY FINDING: Gel-Exo promoted motor function and electrophysiological performance in mice with SCI, suggesting enhanced neurogenesis.
Frontiers in Genetics, 2022 • July 12, 2022
In this study, in total, sixteen variants were detected in twelve OCA cases including fourteen recurrent variants and two novel variants. In summary, we reported sixteen different variants in twelve O...
KEY FINDING: Ten TYR-related and two OCA2-related patients were identified with 16 different variants with potential pathogenicity.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study explored the potential clinical application roles of hADSCs-Exos encapsulated in functional PF-127 hydrogel in wound healing. The hADSCs-Exos/PF-127 combination could promote wound healing ...
KEY FINDING: PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased expression of Ki67, α-SMA, and CD31, facilitated collagen synthesis (Collagen I, Collagen III), up-regulated expression of skin barrier proteins (KRT1, AQP3), and reduced inflammation (IL-6, TNF-α, CD68, CD206).
STAR Protocols, 2022 • September 16, 2022
Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-dependent pathway that maintains telomeres. Here, we describe a protocol to stimulate the formation of ALT-asso...
KEY FINDING: ABA-dependent tethering of PML-IV to telomeres induces telomere clustering.
Cells, 2022 • August 4, 2022
This study assessed how macrophage conditioned medium affects the phagocytic ability and gene expression pattern in OECs and the influence of the growth factors VEGF and PDGF. Macrophages exposed to co...
KEY FINDING: Combined VEGF + PDGF reduced translocation nuclear factor kappa B p65 in macrophages without altering pro-inflammatory cytokines.
Neural Regeneration Research, 2023 • March 1, 2023
This study investigates the role of DUSP2, a phosphatase, in axon regeneration of Mauthner cells (M-cells) in zebrafish after spinal cord injury. The researchers used CRISPR/Cas9 to knock out the dusp...
KEY FINDING: DUSP2 knockout in zebrafish promotes M-cell axon regeneration at an early stage after birth (within 8 days).
Oxidative Medicine and Cellular Longevity, 2022 • August 22, 2022
This review explores the potential of polyphenols in targeting oxidative stress in spinal cord injury (SCI). Oxidative stress plays a significant role in the pathophysiology of SCI, influencing interr...
KEY FINDING: Polyphenols, such as epigallocatechin gallate (EGCG), resveratrol, and quercetin, exhibit antioxidant, anti-inflammatory, and neuroprotective properties that can mitigate oxidative stress and inflammation following SCI.
Frontiers in Pharmacology, 2022 • August 22, 2022
The study investigated the neuroprotective effects of total flavonoids of hawthorn leaves (TFHL) on spinal motor neurons (SMNs) after spinal cord injury (SCI). TFHL was administered to rats with SCI,...
KEY FINDING: TFHL improved the neuromotor function recovery in rats after SCI, as assessed by BBB scoring.
Frontiers in Psychiatry, 2022 • August 23, 2022
This study used integrated co-expression network analysis to identify tissue-specific gene modules and functions in major depressive disorder (MDD) and bipolar disorder (BP). The analysis revealed nin...
KEY FINDING: Nine tissue-specific modules were identified in MDD across four tissues, and six modules in BP.
Neurochemical Research, 2022 • September 14, 2022
This study investigates the effects of the ROCK inhibitor Y27632 on astrocytes and functional recovery in a rat model of SCI. The findings demonstrate that Y27632 promotes functional recovery after SC...
KEY FINDING: Y27632 treatment improved functional recovery of SCI and elevated the proliferation and migration abilities of the astrocytes.