Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 51-60 of 136 results
BMC Research Notes, 2022 • February 9, 2022
This study investigates the impact of gut microbiota modulation on functional recovery after traumatic peripheral nerve injury (TPNI) in mice. Using antibiotic (ABX)-induced dysbiosis and probiotic (P...
KEY FINDING: Antibiotic (ABX) treatment before a peripheral nerve injury significantly impaired functional recovery in mice.
Frontiers in Neuroscience, 2022 • February 17, 2022
This study demonstrates that non-invasive spinal neuromodulation can acutely alter motor and sensory function in the anorectum of individuals with spinal cord injury (SCI). The study also presents a c...
KEY FINDING: Spinal neuromodulation can acutely change motor and sensory function of the anorectum.
Spinal Cord, 2022 • March 25, 2022
The AWMF e.V. guideline for NBD in SCI/D aims to provide practice-oriented support for the care of patients with NBD resulting from congenital or aquired SCI/D. Individual bowel management must be dev...
KEY FINDING: Individual bowel management must be developed on the basis of an adequate diagnosis and considering the different lesion types.
European Journal of Physical and Rehabilitation Medicine, 2022 • October 1, 2022
The study aimed to evaluate the performance of a prediction model, previously validated for traumatic SCI, in predicting bowel management independence one year after ischemic SCI. The model, based on ...
KEY FINDING: The prediction model showed fair discrimination, with an area under the ROC curve of 0.780 (95% confidence interval=0.702-0.860).
J. Pers. Med, 2022 • July 14, 2022
This review discusses neurogenic bowel dysfunction after spinal cord injury, covering gastrointestinal innervation, pathophysiology, and recent guidelines for assessment and management. Management str...
KEY FINDING: SCI results in neurologic dysfunction characterized by dysmotility of the GI tract, weakness of the pelvic floor and rectal sphincters, and impaired sensation.
Spinal Cord, 2022 • July 27, 2022
This randomised controlled trial compared the squeeze-tube and catheter methods of micro enema delivery in people with recent SCI. The study found that the squeeze-tube method is as good as or better ...
KEY FINDING: The mean between group difference for the time to complete bowel care was −0.5 min (−2.8 to 1.8), where a negative value favours the catheter method.
The Journal of Spinal Cord Medicine, 2021 • May 24, 2019
This phase Ia clinical trial assessed the safety and tolerability of a single intravesical instillation of Lactobacillus rhamnosus GG in patients with neuropathic bladder. The study included five chil...
KEY FINDING: Intravesical instillation of Lactobacillus rhamnosus GG was well-tolerated by all patients, with no immediate adverse events.
Spinal Cord, 2020 • November 11, 2019
Neurogenic bowel dysfunction is one of the most disabling impairments caused by SCI and achieving effective bowel management is a lifelong challenge. People with SCI are at risk of developing infectio...
KEY FINDING: The primary outcome is the difference in the incidence of AAD between the probiotic and placebo groups at the end of antibiotic use, probiotic use, and two weeks thereafter.
Spinal Cord, 2020 • April 1, 2020
Between 50 and 80% of the participants studied reported improvements in bowel function and/or management post-EAW training. EAW training appeared to mitigate SCI-related bowel dysfunction and the pote...
KEY FINDING: At least 5/10 participants reported improvements with frequency of bowel evacuations, less time spent on bowel management per bowel day, fewer bowel accidents per month, reduced laxative and/or stool softener use, and improved overall satisfaction with their bowel program post-EAW training.
PLOS ONE, 2020 • January 15, 2020
This study demonstrates that a unilateral cervical spinal contusion in rats induces a transient change in the microbiota composition. This SCI-induced gut dysbiosis is involved in the development of ...
KEY FINDING: Spinal cord injury in rats induces dysbiosis and anxiety-like behavior.