Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 11-20 of 136 results
Neurogastroenterol Motil, 2023 • November 1, 2023
This study demonstrates resiliency of the ICC-MP in neurogenic bowel following SCI, unlike seen in other related disease states. Significant male and female distal colon ICC proliferation and increase...
KEY FINDING: Myenteric plexus ICC (ICC-MP) exhibited increased cell counts 3 days following SCI in male rats, but did not significantly increase in females until 3 weeks after SCI.
Scientific Reports, 2023 • August 16, 2023
The study investigates the microbiome composition of skin and pressure injuries (PI) in individuals with spinal cord injury (SCI). It aims to understand the differences in bacterial communities betwee...
KEY FINDING: Skin had lower microbial diversity compared to pressure injuries (PI).
International Journal of Surgery Case Reports, 2023 • August 31, 2023
This case report describes a 65-year-old woman who developed difficult tracheostomy decannulation due to upper airway obstruction, which was attributed to nasogastric tube syndrome (NGTS). The patient...
KEY FINDING: The patient experienced severe inspiratory difficulty and supraglottic swelling, completely covering the opening of the glottis, when tracheostomy decannulation was attempted.
Neural Regeneration Research, 2024 • March 1, 2024
This review summarizes the relationship between gut microbiota and spinal cord injury (SCI). It highlights the frequent occurrence of intestinal dysfunction and gut dysbiosis in SCI patients. The revi...
KEY FINDING: Gut dysbiosis in SCI patients profoundly influences multiple organs and systems, potentially leading to metabolic syndrome, inflammatory bowel disease, and depression.
Annals of Medicine, 2023 • October 6, 2023
This meta-analysis investigates the association between SCI and intestinal flora in animal models, exploring characteristic changes in gut microbiota. The study found that SCI in animal models leads t...
KEY FINDING: Spinal cord injury significantly decreased the richness and evenness of intestinal flora in experimental animals.
Trauma Surg Acute Care Open, 2024 • January 1, 2024
The authors found that the majority of patients received SUP, generally with histamine receptor antagonists. Furthermore, there was no statistically significant difference between the rate of CSGIB wi...
KEY FINDING: Those receiving SUP demonstrated longer hospital and intensive care stays.
Spinal Cord, 2024 • March 22, 2024
This sub-group analysis of a multicentre, randomised, placebo-controlled trial investigated the efficacy of Lactobacillus casei Shirota (LcS) in preventing antibiotic associated diarrhoea (AAD) in pat...
KEY FINDING: The LcS group had a significantly lower incidence of AAD at 30 days after finishing the antibiotic course (28.0 v 53.3%, RR: 95% CI: 0.53, 0.31–0.89; z = 2.5, p = 0.01).
bioRxiv, 2024 • June 8, 2024
This study establishes that SCI-triggered enteric pathologies are able to be modified by the intrinsic intestinal environment. The composition of the microbiome is therefore not solely responsible for...
KEY FINDING: Inulin supplementation improves gut transit and prevents ENS atrophy in a murine model of SCI.
Antioxidants, 2022 • November 12, 2022
The study investigated the expression of H2S-metabolizing enzymes in intestinal biopsies from healthy individuals and IBD patients, across different age groups. Immunohistochemical staining was used t...
KEY FINDING: Healthy adults showed a trend towards lower expression of H2S-metabolizing enzymes compared to healthy children, indicating an age-related decrease.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
This systematic review aimed to evaluate the evidence supporting prophylactic cholecystectomy in individuals with SCI and cholelithiasis. The review analyzed studies identified from Medline, Cochrane,...
KEY FINDING: The literature search identified only retrospective observational studies, with no prospective cohort studies comparing prophylactic cholecystectomy to conservative management in individuals with SCI and gallstone disease.