Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 201-210 of 217 results
Environmental Epigenetics, 2016 • September 16, 2016
The review summarizes the evidence linking BPA exposure to obesity and the involvement of epigenetic mechanisms. Early-life exposure to BPA is particularly effective in predisposing individuals to wei...
KEY FINDING: Early-life exposure to BPA can predispose individuals to weight gain and metabolic disturbances such as obesity and diabetes.
Cardiovasc Diabetol, 2018 • May 10, 2018
This study investigated the effect of linagliptin on endothelial function and postprandial lipid levels in subjects with coronary artery disease (CAD) and early type 2 diabetes mellitus (T2DM). The re...
KEY FINDING: Linagliptin treatment did not significantly improve flow mediated dilation (FMD) in patients with CAD and early T2DM compared to placebo.
PPAR Research, 2018 • June 21, 2018
This study evaluated the effect of simultaneous activation of PPAR-γ and PKA on promoting locomotor recovery in SD rats, the expression of the inflammatory factor NF-κB, survival of mature neurons, an...
KEY FINDING: The combination of rosiglitazone and forskolin resulted in better locomotor recovery in SD rats after SCI compared to either treatment alone.
Neural Regeneration Research, 2018 • September 1, 2018
The study investigated the protective effect of apocynin, a NOX inhibitor, in rat diabetic neuropathy. Streptozotocin-induced diabetic rats were treated with apocynin for 4 weeks, and mechanical hyper...
KEY FINDING: Streptozotocin injection reduced pain threshold in analgesimeter, but not in aesthesiometer, in rat models. Apocynin treatment increased pain threshold dose-dependently.
Neural Regeneration Research, 2018 • October 1, 2018
This review discusses the therapeutic potential and underlying mechanisms of melatonin for the treatment of SCI, including its antioxidative, anti-inflammatory, and antiapoptotic effects. Melatonin's ...
KEY FINDING: Melatonin has antioxidative properties, which help reduce oxidative stress and damage to neurons during the progress of SCI by regulating levels of MDA, GSH and SOD.
J Neurotrauma, 2021 • February 1, 2021
This study investigates the effects of low-dose, site-directed estrogen delivery via nanoparticles on spinal cord injury (SCI) in rats. The researchers hypothesized that this method would reduce infla...
KEY FINDING: Site-directed estrogen delivery reduced lesion size, reactive gliosis, and glial scar formation compared to controls.
Biochim Biophys Acta Mol Basis Dis, 2020 • March 1, 2020
This study investigated the effects of a high fat diet (HFD) on oligodendrocytes and myelin in the central nervous system (CNS) of mice. Results showed that HFD consumption led to a loss of oligodendr...
KEY FINDING: Chronic high fat diet (HFD) consumption promotes loss of oligodendrocyte progenitors across the brain and spinal cord.
Journal of Molecular Medicine, 2020 • December 20, 2019
This study investigates the role of platelet-derived factors on placental βhCG synthesis. It demonstrates that maternal platelets can be detected at the early maternal-fetal interface and that platele...
KEY FINDING: Maternal platelets can be detected on the surface of placental villi and in intercellular gaps of trophoblast cell columns from gestational week 5 onwards.
Archives of Public Health, 2020 • March 24, 2020
This study assessed vitamin D deficiency prevalence in 34,417 pregnant women in Shanghai between 2014 and 2017. The study found a high prevalence of vitamin D deficiency among these women. Vitamin D l...
KEY FINDING: A large majority (98.4%) of pregnant women in Shanghai did not have adequate vitamin D levels, with 70% being severely deficient or deficient.
International Journal of Medical Sciences, 2020 • July 6, 2020
The study identifies shared biological pathways between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM) by analyzing gene expression data. Lipid metabolism is highlighted as a key interse...
KEY FINDING: 113 communal differentially expressed genes (DEGs) were identified between PD and T2DM.