Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury

This study investigates how two drugs, rosiglitazone and forskolin, can protect the spinal cord after an injury in rats. Rosiglitazone reduces inflammation, while forskolin promotes nerve regeneration. The researchers found that using both drugs together led to better recovery of movement compared to using either drug alone. This suggests that combining anti-inflammatory and nerve-regenerating approaches may be beneficial after spinal cord injury. The study also looked at how these drugs affect the levels of certain proteins in the spinal cord, providing insights into the biological mechanisms behind the observed improvements.

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  The combination of rosiglitazone and forskolin resulted in better locomotor recovery in SD rats after SCI compared to either treatment alone.
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  In vitro, activation of PPAR-γ (by rosiglitazone) promoted neural stem cell proliferation but inhibited PKA expression and neuronal formation.
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  In vivo, the rosiglitazone + forskolin group showed higher MAP2 and NeuN expression and lower NF-κB expression compared to the rosiglitazone or forskolin groups alone.