Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 851-860 of 904 results
International Journal of Molecular Sciences, 2020 • May 4, 2020
Neurodegenerative disorders (NDs) are a growing problem worldwide, and current treatments are limited to addressing symptoms rather than underlying mechanisms. Biomaterials offer a promising therapeut...
KEY FINDING: Hydrogels serve as effective scaffolds for stem cell culture and differentiation, while also acting as carriers for growth factors that support cell growth.
Regenerative Biomaterials, 2020 • September 30, 2019
The study focuses on fabricating aligned 3D porous scaffolds from biodegradable waterborne polyurethane (PU) emulsion via directional freeze-drying, ensuring a green process without organic byproducts...
KEY FINDING: Aligned 3D porous PU scaffolds were successfully prepared using a green process, demonstrating a more suitable structure for anisotropic tissue repair compared to random porous scaffolds.
npj Regenerative Medicine, 2020 • January 1, 2020
This study investigates the use of porous collagen-based scaffolds (PCSs) for delivering neural stem cells (NSCs) to spinal cord injury (SCI) sites to promote regeneration. The findings show that PCS ...
KEY FINDING: Porous collagen scaffolds (PCS) seeded with NSCs significantly improved locomotion recovery in mice with dorsal column crush SCI, with performance approaching that of uninjured animals after 12 weeks.
STEM CELLS Transl Med., 2020 • September 1, 2020
This study investigates the neurotrophic effects of decellularized skeletal muscles using a 3D organotypic culture system. The findings demonstrate that decellularized muscle scaffolds attract and sup...
KEY FINDING: Decellularized muscles retain structural proteins of the ECM of both skeletal muscle and peripheral nervous system.
Journal of Biological Engineering, 2020 • July 27, 2020
Fibrin hydrogels are promising natural polymers for neural tissue engineering, offering biocompatibility and modifiability for carrying cells and therapeutic factors. Challenges remain in the clinical...
KEY FINDING: Fibrin hydrogels offer excellent biocompatibility, flexibility, and plasticity, making them suitable for neural tissue engineering and SCI repair.
Neural Regeneration Research, 2021 • January 1, 2021
This study investigates the effectiveness of a combined approach using laminin-coated filaments, Schwann cells, and glial cell line-derived neurotrophic factor (GDNF) to promote axonal regeneration in...
KEY FINDING: Channels with filaments significantly reduced the lesion cavity, astrocytic gliosis, and inflammatory responses at the graft-host boundaries.
Neural Regeneration Research, 2021 • February 1, 2021
Hydrogel-based drug delivery strategies offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associ...
KEY FINDING: Hydrogel pore size can be varied to control drug release, with larger pore sizes leading to faster drug release.
Nature Communications, 2020 • September 9, 2020
This study presents a pH-responsive immunomodulatory strategy for neural regeneration using electrospun fibers that release IL-4 plasmids to suppress inflammation and promote neural differentiation. T...
KEY FINDING: The microenvironment-responsive immunoregulatory electrospun fibers were able to shift immune cell subtypes to down-regulate the acute inflammation response.
Dose-Response: An International Journal, 2020 • July 1, 2020
The study successfully developed a biofabricated nano-cerium oxide loaded PCL polymer with RVL, characterizing the nanomaterial through various analytical techniques. The CeO2-PCL/RVL bionanomaterials...
KEY FINDING: Nano CeO2 particles assembled onto PCL/RVL were successfully synthesized using a biocompatible ionic liquid.
J Mech Behav Biomed Mater, 2020 • October 1, 2020
This study demonstrates that chronic spinal cord glial scars possess decreased Young’s modulus that propagates outward from the injury core. The most significant features of the chronic scar included ...
KEY FINDING: The chronic spinal cord injury scar has decreased Young’s modulus compared to naïve tissue.