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  3. Regenerative Medicine
  4. 3D Printed Neural Regeneration Devices

3D Printed Neural Regeneration Devices

Adv Funct Mater, 2020 · DOI: 10.1002/adfm.201906237 · Published: January 3, 2020

Regenerative MedicineBiomedical

Simple Explanation

Neural regeneration devices can be 3D printed to create anatomically accurate geometries that mimic the nervous system, allowing for advanced neural regeneration. 3D printing allows for precise control over cell placement and incorporation of therapeutic biomolecules, offering advantages over traditional methods. These 3D-printed platforms can be used to create biomimetic scaffolds for clinical implants to treat neurological diseases and injuries, as well as in vitro platforms for drug screening and personalized healthcare.

Study Duration
Not specified
Participants
Animal models
Evidence Level
Not specified

Key Findings

  • 1
    3D printing offers vital features such as coupling with 3D imaging, robotics-based biomanufacturing, compatibility with multiple material sets, and rapid prototyping.
  • 2
    The design of 3D printed neural regeneration devices requires careful consideration of printing technology, biocompatible materials, and replication of target structures.
  • 3
    Living scaffold printing involves a 'one-pot' combination of 3D printing and bioprinting, which requires multiple biomaterials and careful control of the printing process to maintain cell viability.

Research Summary

3D printing offers a promising approach to neural regeneration by enabling the creation of patient-specific scaffolds with precise control over geometry, mechanics, and biology. The development of 3D in vitro platforms, such as nervous systems-on-a-chip, can enhance the translatability of neural regeneration treatments and therapeutics and be utilized for drug testing. Despite significant advances, challenges remain in material selection, cell survival, and the incorporation of vascular networks into 3D printed neural regeneration devices.

Practical Implications

Personalized Medicine

3D printing allows for the creation of patient-specific implants, tailored to individual anatomies and injury profiles.

Drug Discovery

3D in vitro platforms can be used for drug screening and personalized healthcare, accelerating the development of new therapies.

Complex Tissue Engineering

3D printing enables the creation of complex tissue architectures, mimicking the native nervous system and facilitating tissue regeneration.

Study Limitations

  • 1
    Limited selection of neural cells studied.
  • 2
    Need for improved vascular networks in scaffolds.
  • 3
    Challenges in finding optimal biomaterial and cell combinations.

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