Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 781-790 of 904 results
Stem Cells International, 2018 • March 27, 2018
This study explores a novel approach to spinal cord injury (SCI) treatment using a combination of dental pulp stem cells (DPSCs), basic fibroblast growth factor (bFGF), and a heparin-poloxamer (HP) hy...
KEY FINDING: Transplanted HP hydrogel containing DPSCs and bFGF had a significant impact on spinal cord repair and regeneration.
J Neural Eng, 2018 • October 1, 2018
This study demonstrates that PVDF-TrFE scaffolds with aligned fibers can support the extension of SC-neurites and myelination, suggesting their potential in spinal cord repair. The electrospinning tec...
KEY FINDING: PVDF-TrFE scaffolds support the growth of SCs and the extension of neurites. Coating the scaffolds with Matrigel further enhances this growth and extension.
BioMed Research International, 2018 • April 1, 2018
Biomaterial scaffolds show great potential in CNS regeneration by providing tissue repair and functional recovery. They are applied predominantly as hydrogels and biodegradable scaffolds. Biomaterial ...
KEY FINDING: Biomaterial scaffolds can mimic the native extracellular matrix (ECM), providing specific microenvironmental cues to enhance cell survival, infiltration, and differentiation in CNS regeneration.
Trials, 2018 • May 10, 2018
This study is a randomized controlled trial designed to evaluate the non-inferiority of bioactive glass (BaG) compared to autologous bone graft (ABG) in treating tibial and femoral non-unions using th...
KEY FINDING: The primary endpoint of the study is union achieved 1 year after surgery.
International Journal of Nanomedicine, 2018 • May 7, 2018
The study fabricated a three-dimensional hierarchically aligned fibrin hydrogel (AFG) to mimic the spinal cord tissue environment and promote tissue regeneration after spinal cord injury. Implantation...
KEY FINDING: Host cells rapidly invaded the aligned fibrin hydrogels, forming aligned tissue cables within the first week, followed by axonal regrowth in the rat spinal cord injury model.
Molecular Therapy: Nucleic Acids, 2018 • June 1, 2018
This study demonstrates the potential of combining LNA-modified AON gapmers with a fibrin hydrogel for in situ gene silencing at a spinal cord injury (SCI) lesion site. The fibrin hydrogel acts as a d...
KEY FINDING: LNA gapmers were effectively developed against RhoA and GSK3b, two gene targets aiming at enhancing axonal regeneration.
Cell Transplantation, 2018 • June 1, 2018
This study investigates the transplantation of NeuroRegen scaffolds with human umbilical cord mesenchymal stem cells (MSCs) into two acute complete SCI patients. The patients were diagnosed as complet...
KEY FINDING: The sensory level expanded below the injury level in both patients, and they regained sense function in bowel and bladder.
Frontiers in Neurology, 2018 • May 22, 2018
This study details the design and sizing of a guiding device for precision grafting of peripheral nerves in complete thoracic spinal cord injury (SCI). The device's design and sizing are compared to a...
KEY FINDING: A set of seven guiding device sizes can accommodate the range of human thoracic spinal cord sizes (T2-T12) with acceptable error.
Biotechnology Reports, 2018 • January 1, 2018
This study explores the use of the Proseek Single-Plex Protein Assay Kit System for detecting sAxl and Gas6 in HGG patients' blood, aiming for more sensitive detection than standard ELISA methods. The...
KEY FINDING: The Proseek method demonstrates higher sensitivity in detecting lower concentrations of Gas6 compared to the DuoSet sandwich ELISA method.
Biomaterials, 2019 • April 1, 2019
This review comprehensively reports technologies related to ex vivo models and lab-on-a-chip devices used to model regeneration in the peripheral and central nervous systems. It discusses the necessit...
KEY FINDING: Animal models often fail in clinical trials due to differences in healing mechanisms, injury replicability, and biological mismatches between humans and animals.