Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 751-760 of 904 results
Frontiers in Pharmacology, 2017 • May 10, 2017
This review discusses the limitations of current pharmacological treatments for SCI and highlights the potential of biomaterials for local, controlled drug delivery to address these limitations. Vario...
KEY FINDING: Hydrogels, particles, and fibers/conduits are commonly used biomaterials for CNS drug delivery, providing a matrix for tissue restoration and tunable drug release.
Organogenesis, 2017 • May 8, 2017
Spinal cord injury (SCI) often results in substantial disability. Neural stem cells (NSCs) are a promising strategy for SCI repair, but NSCs rarely differentiate into neurons because of the adverse mi...
KEY FINDING: Myelin-associated inhibitors (MAIs) inhibit neuronal differentiation of NSCs.
Pharmaceuticals, 2017 • July 5, 2017
This review discusses therapeutic neuro-protective and neuro-regenerative strategies for spinal cord injury (SCI) treatment, focusing on nanofibers as drug delivery systems. It highlights the potential...
KEY FINDING: Nanofiber scaffolds can support graft cells, reconstruct tissue loss, alleviate inflammation, improve axonal regeneration, and act as drug delivery systems in SCI treatment.
Neural Regeneration Research, 2017 • June 1, 2017
Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineerin...
KEY FINDING: PEG resists nerve fiber degeneration, reduces the inflammatory response, inhibits vacuole and scar formation, and protects nerve membranes in the acute stage of spinal cord injury.
STEM CELLS AND DEVELOPMENT, 2017 • August 29, 2017
This study investigates the variable neuronal growth support capacities of different mixed astrocyte populations derived from mouse embryonic stem cells (mESCs). Two distinct populations, one primaril...
KEY FINDING: Motoneurons and V2a interneurons extended significantly longer neurites on substrates derived from protoplasmic astrocytes compared to those from fibrous astrocytes.
Scientific Reports, 2017 • August 4, 2017
The study investigates a nanoparticle-based approach to deliver fidgetin siRNA into adult rat DRG neurons to promote nerve regeneration. Results demonstrate that partial knockdown of fidgetin increase...
KEY FINDING: Nanoparticle delivery of fidgetin siRNA increases labile microtubule mass in the axons of cultured rat adult DRG neurons.
World J Exp Med, 2017 • August 20, 2017
The incidence of spinal cord injury (SCI) has been gradually increasing, and the treatment has troubled the medical field all the time. According to the preliminary experiments, we would like to provi...
KEY FINDING: The proposed biomimetic spinal cord combines the advantages of an acellular scaffold and a thermosensitive gel for SCI repair.
Scientific Reports, 2017 • August 17, 2017
The study demonstrates that PgP can form polyplexes with pDNA that remain stable in the presence of competing polyanions and provide protection from serum nucleases. PgP/pDNA polyplexes can be stored ...
KEY FINDING: PgP/pDNA polyplexes exhibit increased stability in the presence of a competing anionic macromolecule (heparin) relative to bPEI.
Nature Communications, 2017 • August 1, 2017
The study demonstrates that an injectable hydrogel, I-5, can effectively eliminate cystic cavities that form after spinal cord injuries in rats. I-5 hydrogel promotes extracellular matrix remodeling b...
KEY FINDING: I-5 hydrogel injection almost completely eliminates cystic cavities in a rat spinal cord injury model.
ACS Biomater Sci Eng, 2017 • July 10, 2017
The study successfully fabricated collagen microspheres encapsulating astrocytes, with control over microsphere size via flow rate and reduced degradation via crosslinking with 4S-StarPEG. The encapsu...
KEY FINDING: Collagen microspheres can be efficiently generated by injecting a mixture of collagen and astrocytes into a cell culture medium, with size controllable via the flow rate.