Biomedical Research

KEY FINDING: Aligned electrospun fibers lead to neurite extension along the length of the aligned fibers, a finding repeated in vivo where axons grew into the injured region on aligned fibrous scaffolds.

KEY FINDING: Astrocytes can be successfully grown on a 3D collagen matrix, mimicking the in vivo architecture of the spinal cord.

KEY FINDING: DA-loaded polymeric micelles (DA/MPEG-PCL micelles) were successfully prepared with a diameter of approximately 25 nm and sustained DA release in vitro.

KEY FINDING: Aligned axon regeneration was observed as early as one week post-injury, indicating the contact guidance role of the scaffold.

KEY FINDING: A novel material was created by grafting the IGF-I binding peptide sequence from IGFBP-5 onto alginate.

KEY FINDING: NGF therapy using US-mediated NGF/PLGA NBs destruction significantly increased NGF expression in injured spinal cords of rats.

KEY FINDING: In contrast to scars in other mammalian tissues, CNS tissue significantly softens after injury.

KEY FINDING: The study found that even a small amount of aligned microgels (as low as 1 vol%) can guide nerve cells to grow in a specific direction within the Anisogel.

KEY FINDING: Co-transplantation of ASCs and MSCs in a multichannel polymer scaffold significantly improved nerve function recovery in rats after spinal cord injury, as shown by BBB scores and electrophysiological test results.

KEY FINDING: EPCs can be mobilized from bone marrow and recruited to injured tissue to contribute to neovascularization and tissue repair.