Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 761-770 of 904 results
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017 • January 1, 2017
Spinal cord injury (SCI) leads to loss of motor and sensory neurons. Stem cell (SC)‑based therapies promote neuronal regeneration after SCI by releasing trophic factors or differentiating into neural ...
KEY FINDING: MSCs create a favorable microenvironment for neuronal regeneration by counteracting inflammation and apoptosis and promoting axonal regeneration through paracrine effects or differentiation into neurons or glial cells.
Scientific Reports, 2017 • October 9, 2017
The study demonstrates that degummed Antheraea pernyi filaments (DAPF) support excellent outgrowth of CNS neurons in vitro, due to cell attachment to the high density of arginine-glycine-aspartic acid...
KEY FINDING: DAPF promotes cell adhesion, contact guidance, and rapid neurite extension in CNS neurons, with the RGD tripeptide sequence playing a key role in facilitating cell binding and growth.
JOURNAL OF NEUROTRAUMA, 2018 • February 1, 2018
This study investigates the use of rolipram (Rm)-loaded polymeric micelle nanoparticles (PgP) to reduce secondary injury after spinal cord injury (SCI) in rats. The results demonstrate that PgP can ef...
KEY FINDING: PgP nanoparticles increased rolipram's water solubility by approximately 6.8 times, enabling efficient drug loading.
Front. Syst. Neurosci., 2017 • September 27, 2017
This mini-review focuses on recent publications exploring the use of graphene-derived materials (GDMs) to interface with the spinal cord, including in vivo, ex vivo, and in vitro models. Studies have ...
KEY FINDING: rGO scaffolds implanted in hemisected rat spinal cords formed a soft interface with neural tissue, did not augment fibroglial scars, and facilitated cellular and molecular scaffold infiltration, including vimentin+ and PDGFRβ+ cells, and M2-like macrophages.
Journal of Visualized Experiments, 2017 • November 3, 2017
This study details a surgical technique for transplanting Schwann cells (SCs) within a PVDF-TrFE conduit to bridge a completely transected rat spinal cord. The method aims to promote axon regeneration...
KEY FINDING: GFP-SCs were evenly distributed along and within the conduit after transplantation into the transected spinal cords of rats.
Materials, 2017 • November 23, 2017
This study investigates the in vitro dissolution behavior of 45S5 bioactive glass (BG)-based scaffolds with different morphologies using micro-computed tomography (µCT). The scaffolds were fabricated ...
KEY FINDING: Both scaffold groups showed similar structural alteration upon immersion, with an increase in surface area and scaffold volume, and a decrease in density.
Neural Regeneration Research, 2017 • October 1, 2017
The study investigates the potential of PEI-ALG nanoparticles to deliver Nis-siRNA to the spinal cord, aiming to inhibit nischarin expression and promote motor function recovery after SCI. The results...
KEY FINDING: Nischarin expression was significantly decreased in the PEI-ALG/Nis-siRNA group compared with the SCI group, PEI-ALG group, and PEI-ALG/Ctl-siRNA group.
Scientific Reports, 2017 • December 15, 2017
This study introduces a novel biodegradable gelatin-BVSM conduit for peripheral nerve repair, addressing limitations of autologous and allogenic nerve grafts. The gelatin-BVSM conduit demonstrates pro...
KEY FINDING: The gelatin-BVSM conduits exhibited suitable mechanical strength, were hydrophilic, and non-cytotoxic to Schwann cells.
NEURAL REGENERATION RESEARCH, 2017 • November 1, 2017
The complex pathophysiology of spinal cord injury explains the current lack of effective therapies for neuronal regeneration and motor function recovery. Developing suitable scaffolds for spinal cord ...
KEY FINDING: Mimicking the native extracellular matrix (ECM) of the spinal cord is a successful approach in designing neural biomaterials. This provides an artificial pro-regenerative environment at the injury site to facilitate neural repair.
J Neural Eng, 2018 • April 1, 2018
The three-component hydrogel presented here has the potential to provide cues to direct differentiation in vivo to encourage regeneration of the central nervous system. Transplantation of hydrogels op...
KEY FINDING: Our results demonstrate that we can achieve a significant increase in oligodendrocyte differentiation of NPCs compared to standard culture conditions using a three- component biomaterial composed of collagen, hyaluronic acid, and laminin that has mechanical properties matched to those of neonatal neural tissue.