Multifunctional biomimetic spinal cord: New approach to repair spinal cord injuries

Spinal cord injury (SCI) is a serious condition with limited regeneration ability in the central nervous system. Current treatments often struggle with the complex microenvironment at the injury site. This paper proposes a new biomimetic spinal cord design that combines an acellular scaffold and a thermosensitive gel to promote nerve regeneration and reduce the negative effects of glial scar tissue. The scaffold aims to mimic the structure of the spinal cord, distinguishing between gray and white matter regions to guide cell differentiation and promote spinal cord tissue regeneration.

• 1
  The proposed biomimetic spinal cord combines the advantages of an acellular scaffold and a thermosensitive gel for SCI repair.
• 2
  The design includes the controlled release of basic fibroblast growth factor (BFGF) in the spinal lesion area to promote nerve regeneration.
• 3
  The scaffold distinguishes between gray and white matter regions to induce directed cell differentiation and spinal cord tissue regeneration.