Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 731-740 of 904 results
Surg Neurol Int, 2016 • August 23, 2016
This study investigates the biocompatibility of graphene nanoscaffolds in a rat model of spinal cord injury. Graphene's unique properties make it a potential bioscaffold for neuronal regeneration. The...
KEY FINDING: Graphene nanoscaffolds adhered well to spinal cord tissue, showing good integration at the lesion site.
Matrix Biol, 2017 • July 1, 2017
The study explores the use of decellularized mesenchymal ECM to promote neurite outgrowth, comparing it to laminin and fibronectin substrates. Results indicate that SCG neurons extend neurites similar...
KEY FINDING: Average radial neurite extension was equivalent on laminin and on the decellularized ECM, but contrasted with the shorter, curved neurites observed on the fibronectin substrate.
Cells Tissues Organs, 2016 • January 1, 2016
Tissue engineering strategies for SCI are limited by inflammation, leading to secondary damage and inhibiting neuron regeneration. Modulating the immune response towards an anti-inflammatory environme...
KEY FINDING: Biomaterial scaffolds can provide physical guidance for regenerating axons and limit leukocyte infiltration, but their interactions with immune cells are complex and affected by physical and chemical properties.
Cells Tissues Organs, 2016 • January 1, 2016
This paper reviews the use of electrospun fibers for drug delivery in spinal cord injury (SCI) treatment, highlighting their potential to guide axonal regeneration and deliver therapeutic drugs locall...
KEY FINDING: Riluzole and NT-3 were successfully incorporated into electrospun PLLA fibers.
Biomaterials, 2017 • January 1, 2017
The study introduces a novel drug delivery system for minocycline (MH) using metal ion-assisted self-assembled complexes within a hydrogel, designed for local intrathecal administration to treat spina...
KEY FINDING: Local delivery of MH at a dose of 1.3 mg/kg generated significantly higher MH concentration in the local spinal cord tissue than intraperitoneal (IP) injection of 495 mg/kg MH over 5 days.
Frontiers in Neuroscience, 2016 • October 4, 2016
The influence of electrode materials on OEC viability and functionality under biphasic stimulation was examined. Biphasic stimulation at these levels had no negative impact on the cell health of the OE...
KEY FINDING: For the same current input, there was a significantly lower average voltage recorded across the CH samples (147 ± 3 mV) compared to the voltage across the Pt samples (317 ± 5 mV).
Scientific Reports, 2016 • October 24, 2016
The study investigates the chronic effect of micro- and nanostructured surfaces on living brain tissue eight weeks after implantation, focusing on glial scar formation and recording failure. GFAP stai...
KEY FINDING: No significant difference was observed in the severity of gliosis (scar tissue formation) in the vicinity of the different implant surfaces.
Scientific Reports, 2016 • December 6, 2016
This study developed a bFGF-ASC-HP hydrogel for enhanced bFGF delivery to treat spinal cord injuries, combining the benefits of bFGF, ASC, and HP hydrogels. The bFGF-ASC-HP hydrogel was found to signi...
KEY FINDING: The ASC scaffold has a strong affinity for bFGF, enhancing its stability and controlled release.
Biomaterials, 2017 • March 1, 2017
The study evaluated the ability of PgP to deliver siRNA targeting RhoA, a critical signaling pathway activated by multiple extracellular inhibitors of axonal regeneration. Histological analysis at 4 w...
KEY FINDING: PgP/siRhoA polyplexes significantly reduced RhoA mRNA and protein expression for up to 4 weeks post-injury in a rat compression SCI model.
TISSUE ENGINEERING: Part A, 2017 • March 31, 2017
The study introduces a novel scaffold architecture and fabrication technique for spinal cord nerve repair using polycaprolactone (PCL). The scaffolds exhibit significantly higher open volume than stat...
KEY FINDING: The elastic modulus of PCL could be controlled between 2.09 and 182.1 MPa by controlling porosity.