Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 721-730 of 904 results
Regenerative Biomaterials, 2015 • April 7, 2015
Biomaterial-based strategies focus on bridging the spinal cord lesion, providing a favorable substrate, and guiding axonal re-growth. Following SCI, inhibitory mechanisms create a hostile environment,...
KEY FINDING: Multiple inhibitory mechanisms hamper regeneration after spinal cord injury, establishing a hostile environment for neuronal cell growth.
J Neurosci Methods, 2016 • April 1, 2016
This study introduces a semi-automated method for quantifying axon regeneration in spinal cord injury models using poly(lactide co-glycolide) (PLG) bridges. The method utilizes Hessian-based filtering...
KEY FINDING: The semi-automated method accurately counted axons in spinal cord tissue sections.
PLoS ONE, 2016 • January 29, 2016
The study investigates DC-Chol-modified PLGA nanospheres as gene delivery vehicles for spinal cord injury, demonstrating enhanced gene transfection efficiency and reduced cytotoxicity compared to PEI....
KEY FINDING: PLGA/DC-Chol nanospheres are less cytotoxic than PEI both in vitro and in vivo, suggesting a better safety profile.
Acta Biomater, 2016 • April 15, 2016
The study introduces a novel cationic amphiphilic copolymer, poly (lactide-co-glycolide)-graft-polyethylenimine (PgP), as an efficient nonviral vector for nucleic acid delivery to the spinal cord. PgP...
KEY FINDING: PgP micelles efficiently transfect pDNA and siRNA in the presence of 10% serum in neuroglioma (C6) cells, neuroblastoma (B35) cells, and primary E8 chick forebrain neurons (CFN).
J Mater Sci: Mater Med, 2016 • February 19, 2016
This study investigates the potential of using a tissue-engineered construct, consisting of a chitosan–gelatin scaffold seeded with bone marrow mesenchymal stem cells (BMSCs), for prenatal repair of s...
KEY FINDING: The chitosan–gelatin scaffold seeded with BMSCs promoted cell adhesion, spreading, and in vitro viability.
J Biomed Mater Res Part A, 2016 • April 4, 2016
This study investigates the dynamic influence of autocrine ECM, specifically fibronectin (FN), on cell behavior and functional changes during cell development and neuronal process regeneration. The re...
KEY FINDING: FN secreted by MSCs accumulated on the gelatin sponge scaffold and promoted neurite elongation of neuronal differentiating MSCs.
Integr Biol (Camb), 2016 • May 16, 2016
This study investigates the dynamic behaviors of astrocytes within chemically modified fibrin and collagen hydrogels, exploring their potential as growth-permissive substrates for cell transplantation...
KEY FINDING: Astrocytes maintained good viability in both fibrin and collagen hydrogels, suggesting these hydrogels are suitable for astrocyte transplantation.
Biomater Sci, 2016 • June 21, 2016
The study introduces a non-viral, nanoparticle-based method for delivering transcription factors (Sox2 and Olig2) into primary human astrocytes to convert them into neurons and oligodendrocytes. The P...
KEY FINDING: PBAE-based nanoparticles, particularly Polymer 536, can effectively transfect primary human astrocytes with high efficiency and low cytotoxicity, surpassing the performance of commercial reagents like Lipofectamine™ 2000.
Oncotarget, 2016 • July 29, 2016
Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosup...
KEY FINDING: Decellularized liver scaffolds demonstrated an ability to support efficient in vitro recellularization with primary hepatocytes and subsequent perfusion of cells.
Adv Healthc Mater, 2016 • October 1, 2016
This study demonstrates that paclitaxel can be incorporated into electrospun PLA microfibers without modifying their alignment and fiber shape. A local release of paclitaxel from electrospun fibers, i...
KEY FINDING: Paclitaxel can be incorporated into electrospun PLA microfibers without modifying their alignment and fiber shape.