Biomedical Research

KEY FINDING: Platelet-rich plasma group demonstrated a significant increase in the number of regenerating nerve fibers and thickness of the myelin sheath compared with the fibrin group (P < 0.05).

KEY FINDING: Human dental follicle cells (hDFCs) can be induced to express neurogenic markers and are a potential resource for neural regeneration.

KEY FINDING: Stem cells from different origins have been tested for their ability to stimulate nerve regeneration and restore the neuronal circuitry when integrated in the injured site.

KEY FINDING: The postinjury environment of the spinal cord is hostile to regenerative processes due to molecular changes, inflammation, and the creation of a hypoxic environment. This leads to reactive astrogliosis, forming a chemophysical barrier that inhibits regenerative activity.

KEY FINDING: Stem cell-based transplantation shows promise due to direct tissue replacement, neuroprotection, and support for axonal regrowth and neuronal plasticity.

KEY FINDING: The vancomycin-encapsulated hydrogel, when loaded into the microarc-oxidized 3D-printed porous Ti6Al4V implant, exhibits effective antibacterial activity against MRSA both in vitro and in vivo.

KEY FINDING: Hydrogel stiffness was not significantly affected by the ratios of decellularized sciatic nerve (dSN) and spinal cord (dSC) used to create the composite hydrogels.

KEY FINDING: The size of NPs affects how they are taken up by cells, influencing the immune response. Smaller NPs tend to be internalized through different pathways than larger NPs.

KEY FINDING: Spatiotemporal dynamic neuroinflammation plays an important role in secondary injury after SCI. Inflammatory cells and mediators have different roles at different stages of inflammation.

KEY FINDING: At the final FU, the patients of ASIA B, C, and D recovered to E.