Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 641-650 of 904 results
Advanced Science, 2024 • March 22, 2024
The study developed a bifunctional neural stem cell (NSC) delivery system using a temperature-responsive nanohydrogel containing magnetic nanoparticles (MNPs) and methylprednisolone (MP) for spinal co...
KEY FINDING: The delivery system releases MP to reduce inflammation by promoting M2 microglia polarization and inhibiting M1 polarization, reducing neuronal apoptosis.
Cells, 2024 • March 24, 2024
The advance of nanotechnologies for the treatment of refractory spinal cord pathologies requires an in-depth understanding of neurobiological and topographical principles and a consideration of additi...
KEY FINDING: Nanoparticle size, shape, and surface chemistry are critical factors influencing their interaction with biological systems, affecting drug delivery and cellular uptake in SCI treatment.
Frontiers in Molecular Neuroscience, 2024 • April 3, 2024
The study validates nano-pulling's ability to induce axon growth in an in vitro regeneration model using dissected DRG. MNPs are able to penetrate the ganglia and localize inside neuronal cells and wi...
KEY FINDING: Nano-pulling doubles the regeneration rate of axons in DRG explants compared to spontaneous regeneration.
Nanomaterials, 2024 • April 22, 2024
This review explores the potential of α-gal nanoparticles to induce regeneration in adult mice, mimicking the natural regenerative abilities observed in amphibians. The approach focuses on activating ...
KEY FINDING: α-Gal nanoparticles induce rapid and extensive macrophage recruitment in adult mice injuries.
Front. Bioeng. Biotechnol., 2024 • April 19, 2024
This study introduces P-RuFe, a metal-organic framework activated by X-rays, exhibiting neurogenic and neuroprotective properties to repair traumatic SCI by improving the post-injury microenvironment....
KEY FINDING: The combined strategy (P-RuFe and X-ray) reduces immune cell infiltration, correlating with decreased tissue degeneration after SCI.
Journal of Nanobiotechnology, 2024 • May 31, 2024
This study introduces a novel antioxidant strategy for SCI treatment using ZIF-8 encapsulated selenium nanoparticles (SeNPs@ZIF-8) coated with ferrostatin-1 (FSZ NPs). The FSZ NPs demonstrate synergis...
KEY FINDING: SeNPs@ZIF-8 nanoparticles, particularly medium-sized ones (SSe@ZIF-8), exhibit enhanced ROS scavenging ability compared to SeNPs alone, reducing cytotoxicity.
International Journal of Nanomedicine, 2024 • May 8, 2024
This study introduces an innovative approach to treating spinal cord injury (SCI) by using an injectable hydrogel (FTY720-CDs@GelMA) loaded with carbon dots (CDs) and FTY720, combined with neural stem...
KEY FINDING: The FTY720-CDs@GelMA hydrogel significantly enhanced NSC proliferation while promoting neuronal regeneration and synaptic formation, thereby reducing cavity area in the injured spinal cord.
Regenerative Biomaterials, 2024 • April 10, 2024
This study investigates a multifunctional DSCM hydrogel incorporating curcumin and NT-3 for spinal cord injury (SCI) therapy, demonstrating enhanced NSCs proliferation and neuronal differentiation. Th...
KEY FINDING: The integration of both NT-3 and curcumin significantly enhanced NSCs proliferation and their neuronal differentiation.
International Journal of Nanomedicine, 2024 • May 13, 2024
This study investigates the effects of MgAl-LDH nanoparticles of varying sizes on the differentiation of mouse embryonic stem cells (mESCs) into neural progenitor cells (NPCs). The results demonstrate...
KEY FINDING: MgAl-LDH nanoparticles of 100 nm size significantly promote the differentiation of ESCs into NPCs compared to 30 nm and 50 nm sizes.
Bioactive Materials, 2024 • May 7, 2024
This study introduces a novel therapeutic approach for spinal cord injury (SCI) that combines ROS-responsive nanoparticles, a ferroptosis inhibitor prodrug (Feb-1), and mesenchymal stem cells (MSCs). ...
KEY FINDING: The ROS-responsive nanoparticles (ROS Nano@Feb-1) were successfully constructed and can release the drug Feb-1 in response to high ROS levels, which are characteristic of SCI.