Biomedical Research

KEY FINDING: Microneedles can improve the delivery of active substances to enhance bioavailability in tissue repair.

KEY FINDING: Combined treatment of MgFe-LDH/NT3 nanoparticles and ultrasound promoted neural stem cell differentiation into neurons in vitro.

KEY FINDING: Neuroinflammation after spinal cord injury involves a complex interplay of immune cells, cytokines, chemokines, and neurotrophic factors, leading to both tissue damage and repair.

KEY FINDING: Human spinal cord astrocytes (hscAS) promote the adhesion, survival, and neurite outgrowth of human spinal cord neural progenitor cells (hscNPCs) on a linearly ordered collagen scaffold (LOCS).

KEY FINDING: The PME2/PN composite significantly improved osteogenic and angiogenic gene expression, crucial for bone fusion.

KEY FINDING: Fibrin alone initially shows biocompatibility but later triggers chronic microglial activation and axonal degeneration.

KEY FINDING: Hydrogel has a biomimetic structure similar to extracellular matrix, hence has been considered a 3D scaffold for CNS regeneration.

KEY FINDING: The Gel-Cur-M exhibited superior functions compared to Gel and Cur-M alone, which includes ameliorating hyperalgesia while simultaneously improving locomotor and muscular functions after the nerve injury.

KEY FINDING: Customizable, bioengineered tissues can recapitulate CNS structures and functions, representing simplified platforms that allow the systematic assessment of neural development and pathology in vitro.

KEY FINDING: Microneedles can easily pass through physical barriers at wound sites and sustainably release drugs, enhancing drug delivery efficiency.