Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 571-580 of 904 results
Journal of Tissue Engineering, 2023 • January 1, 2023
This study investigates the use of a fibre-hydrogel scaffold to deliver Cx43 antisense oligodeoxynucleotides (asODNs) to minimize secondary injuries and cell death, thereby supporting tissue regenerat...
KEY FINDING: Scaffolds with Cx43asODN, along with NT-3, reduced Cx43 upregulation after spinal cord injury in rats.
中国修复重建外科杂志, 2023 • January 1, 2023
This study investigates the neuroprotective effects of TGTP hydrogel on spinal cord injury in rats. The results demonstrate that TGTP hydrogel effectively promotes motor function recovery, improves my...
KEY FINDING: TGTP hydrogel significantly improved BBB scores in rats with spinal cord injuries compared to the model group, indicating better motor function recovery.
Chinese Journal of Reparative and Reconstructive Surgery, 2023 • January 1, 2023
This study developed a diclofenac sodium-loaded gelatin scaffold with anti-inflammatory activity to promote cartilage regeneration in vivo. The scaffold exhibited suitable pore size, porosity, and cyt...
KEY FINDING: The diclofenac sodium-loaded gelatin scaffold significantly reduced the expression of IL-1β and TNF-α, indicating its anti-inflammatory properties.
Biomaterials, 2023 • April 1, 2023
This study demonstrates that the bulk mechanical properties of the spinal cord change along its length, and that these changes are due to variations in the relative amounts of gray and white matter. T...
KEY FINDING: Bulk spinal cord mechanics differ along anatomical level due to variations in the ratio of white and gray matter.
Sci. Adv., 2023 • February 8, 2023
The study introduces a strategy using click chemistry to enhance donor cell retention and survival on scaffolds, promoting neural regeneration post-SCI. The research combines DBCO-modified scaffolds w...
KEY FINDING: Covalent conjugation (CC) between dibenzocyclooctyne-modified collagen fibers (DBCO-LACF) and azide-modified neural progenitor cells (NPCs) enhanced cell adhesion, retention, and induced cells to spread along the direction of fibers.
Int. J. Mol. Sci., 2023 • January 28, 2023
This review summarizes recent preclinical and clinical studies using biomaterial scaffolds in regenerative therapy for SCI. It also summarizes biomaterial strategies for treatment with simplified resu...
KEY FINDING: Hydrogels, biodegradable scaffolds, micro/nano-fibers, and drug-delivering biomaterials are key categories of biomaterial scaffolds used in spinal cord regeneration. These provide structure, physical support, and biological properties for tissue constructs.
Journal of Materials Science: Materials in Medicine, 2023 • February 21, 2023
This study investigates the potential of cerium oxide nanoparticles (CeONPs) within a gelatin-polycaprolactone scaffold to promote nerve regeneration and alleviate pain in a rat model of spinal cord i...
KEY FINDING: The scaffold containing cerium oxide nanoparticles (Scaffold-CeO2) led to motor improvement and pain reduction in rats with spinal cord injury compared to the SCI group.
Biomimetics, 2023 • February 4, 2023
This study investigates the use of biofunctionalized silk fibroin fibers, produced via straining flow spinning (SFS), as a scaffold for axonal guidance and regeneration following spinal cord injury. T...
KEY FINDING: Silk fibers produced via straining flow spinning (SFS) can effectively guide axonal growth in vitro. Here we show that high-performance fibroin fibers spun with the straining flow spinning (SFS) process can not only be used to direct axonal growth in vitro [19,20], but also that this guiding ability is further modulated through their functionalization with adhesion peptides.
Bioactive Materials, 2023 • January 29, 2023
This study presents a strategy for SCI repair using 3D bioprinting to fabricate living microtissues comprised of NSCs and ECM-like hydrogel, arranged spatially to mimic native nerve fibers. The implan...
KEY FINDING: Living nerve-like fibers modulate the immune microenvironment after SCI by decreasing the number of active macrophages and increasing the ratio of M2 macrophages.
Progress in Biomaterials, 2023 • March 2, 2023
This document is a correction notice for a previously published article in Progress in Biomaterials. The correction pertains to the misspelling of an author's name. The original article focuses on the...
KEY FINDING: The author name Shahrokh Shojaei was misspelled as Shahrokh Shojae in the original article.