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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Biomedical Research

Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.

Showing 331-340 of 904 results

Spinal Cord InjuryNeurologyBiomedical

Delivery of Alginate Scaffold Releasing Two Trophic Factors for Spinal Cord Injury Repair

Scientific Reports, 2015 • September 8, 2015

This study investigates the use of an injectable alginate biomaterial to deliver key growth factors (bFGF and EGF) to improve spinal cord injury (SCI) repair. The results demonstrate that local delive...

KEY FINDING: The alginate scaffold with growth factors reduced the size of the central lesion cavity in the injured spinal cord.

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Spinal Cord InjuryAssistive TechnologyBiomedical

Muscular activity and physical interaction forces during lower limb exoskeleton use

Healthcare Technology Letters, 2016 • October 17, 2016

The study examines the origin of interaction forces between lower limb exoskeletons and their users, investigating the contribution of muscular activity versus exoskeleton movement. The research found...

KEY FINDING: Peak interaction forces are particularly prominent at the anterior aspect of the right leg.

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NeurologyRehabilitationBiomedical

The feasibility of a brain-computer interface functional electrical stimulation system for the restoration of overground walking after paraplegia

Journal of NeuroEngineering and Rehabilitation, 2015 • August 19, 2015

This study demonstrates the feasibility of restoring brain-controlled overground walking after paraplegia due to SCI using a noninvasive BCI-FES system. An individual with SCI was trained to operate a...

KEY FINDING: The participant demonstrated the ability to purposefully operate the BCI-FES system by following verbal cues during overground walking tests.

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Spinal Cord InjuryPharmacologyBiomedical

Using NGF heparin-poloxamer thermosensitive hydrogels to enhance the nerve regeneration for spinal cord injury

Acta Biomater, 2016 • January 1, 2016

This study introduces a novel heparin-poloxamer (HP) thermo-sensitive hydrogel for enhanced nerve regeneration in spinal cord injury (SCI). The NGF-HP hydrogel effectively delivered NGF to the injured...

KEY FINDING: NGF-HP hydrogel showed good morphology and stable bioactivity of NGF in vitro, and enhanced the efficiency of NGF cellular uptake without obvious cytotoxicity.

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Spinal Cord InjuryRegenerative MedicineBiomedical

Effect of hierarchically aligned fibrin hydrogel in regeneration of spinal cord injury demonstrated by tractography: A pilot study

Scientific Reports, 2017 • January 9, 2017

This study demonstrates the potential of aligned fibrin hydrogel (AFG) to promote spinal cord regeneration in canines with spinal cord injury (SCI). Tractography imaging revealed new nerve fibers grow...

KEY FINDING: Tractography revealed new fibers running across the spinal cord injury in three canines treated with AFG.

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NeurologyBiomedical

A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells

Acta Biomater, 2016 • June 1, 2016

This work demonstrates that a peptide sequence taken from tenascin-C can be incorporated into a self-assembling PA nanofiber system while retaining its neurite growth-promoting properties. Inclusion o...

KEY FINDING: The tenascin-C mimetic PA (TN-C PA) was found to self-assemble into supramolecular nanofibers and was incorporated through co-assembly into PA gels formed by highly aligned nanofibers.

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Spinal Cord InjuryNeurologyBiomedical

Improving stand-to-sit maneuver for individuals with spinal cord injury

Journal of NeuroEngineering and Rehabilitation, 2016 • March 9, 2016

This study investigated the effectiveness of two orthotic mechanisms, hip-knee coupling and knee damping, in improving the stand-to-sit (STS) maneuver for individuals with spinal cord injury (SCI) usi...

KEY FINDING: Both the hip-knee coupling and knee damping mechanisms improved coordination between the hip and knee joints during the STS maneuver.

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Assistive TechnologyBiomedical

The Cybathlon promotes the development of assistive technology for people with physical disabilities

Journal of NeuroEngineering and Rehabilitation, 2016 • May 23, 2016

The Cybathlon is a championship for people with disabilities using assistive devices to compete in tasks of daily life. The event aims to promote the development of affordable and functional assistive...

KEY FINDING: Current assistive devices often fall short of meeting the needs of people with disabilities, leading to disappointment and rejection.

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Spinal Cord InjuryRehabilitationBiomedical

Real-time estimation of FES-induced joint torque with evoked EMG Application to spinal cord injured patients

Journal of NeuroEngineering and Rehabilitation, 2016 • June 14, 2016

This paper presents a real-time FES-induced torque estimation system using a wireless portable stimulator. Kalman filter and RNN are used online to identify and predict torque output based on eEMG rec...

KEY FINDING: Both Kalman filter and RNN approaches show clinically feasible results on estimation/prediction of joint torque with eEMG signals only.

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Assistive TechnologyBiomedicalBiomechanics

Optical Enhancement of Exoskeleton-Based Estimation of Glenohumeral Angles

Applied Bionics and Biomechanics, 2016 • April 26, 2016

This paper introduces a hybrid approach to estimate, in real-time, the GH joint angles. This hybrid system is composed of a low-cost marker-based vision system and the rehabilitation robot, overcoming...

KEY FINDING: The results show that, even with significant errors in the marker position estimation, method accuracy is adequate for RAR.

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