Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 91-100 of 904 results
Bioactive Materials, 2023 • January 1, 2023
This study developed an anisotropic Fe3S4 ferrofluid hydrogel (FFH) with sustained release of hydrogen sulfide (H2S) to address the limitations of spinal cord injury (SCI) repair. The FFH demonstrated...
KEY FINDING: Fe3S4 FFH significantly reduced inflammatory factors in LPS-induced BV2 cells in vitro, demonstrating its anti-inflammatory properties.
Theranostics, 2022 • October 31, 2022
This study introduces a novel self-assembled peptide, Nap-E7-YIGSR, coated on aligned PCL fibers, designed to enhance neuronal differentiation of spermatogonial stem cells (SSCs) for spinal cord injur...
KEY FINDING: The Nap-E7-YIGSR peptide enhances the adhesion of SSCs to PCL fibers, improving the material's hydrophilicity and SSC affinity.
Pharmaceutics, 2022 • December 3, 2022
This study evaluates the effects elicited by the minimally invasive acute intraparenchymal injection of an SELP-based injectable corecombinamer named (EIS)2-RGD6 in an in vivo clinically relevant rat ...
KEY FINDING: (EIS)2-RGD6 can be acutely injected in the lesioned spinal cord without inducing further damage.
Journal of Tissue Engineering, 2022 • November 17, 2022
Spinal cord injury leads to significant physical, psychological, and financial burdens, and current treatments often fail to fully repair damaged nerve cells. Inflammation plays a complex role, with e...
KEY FINDING: M1 macrophages exacerbate SCI by secreting inflammatory factors, while M2 macrophages promote tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors.
Bioengineering, 2023 • January 9, 2023
This study explores the combined effects of intensive locomotor training (ILT) and recombinant GABAergic cells on spinal cord injury (SCI)-induced hypersensitivity in rats. The results demonstrate tha...
KEY FINDING: Combined treatment attenuated tactile, heat and cold hypersensitivity in SCI rats.
Materials Today Bio, 2023 • January 7, 2023
This research focuses on developing a dual-targeting liposome (bFGF@Lip-Cp&Rp) to deliver basic fibroblast growth factor (bFGF) for spinal cord injury (SCI) treatment, addressing the challenges of dru...
KEY FINDING: The dual-targeted liposomes (bFGF@Lip-Cp&Rp) can effectively cross the BSCB and accumulate at the injury site in SCI rats.
Frontiers in Bioengineering and Biotechnology, 2023 • January 12, 2023
This study developed a cost-effective and reliable diaphragm pacing (DP) system using bidirectional constant current stimulation for respiratory assistance. The effectiveness of the developed DP syste...
KEY FINDING: The increase of stimulus frequency and amplitude in animals resulted in different degrees of increase in envoked volume.
Frontiers in Bioengineering and Biotechnology, 2023 • January 18, 2023
This review summarizes the current state of hydrogel delivery systems for SSCI treatment. It discusses functional modifications for better therapeutic effects. Hydrogels can be divided into natural an...
KEY FINDING: Natural hydrogels, including proteins, polysaccharides, and acellular matrices, have inherent biocompatibility and bioactivity suitable for biomedical applications.
Frontiers in Cellular Neuroscience, 2023 • February 3, 2023
This Research Topic summarizes important findings related to studies using human induced pluripotent stem cells for translational medicine and provides prospective advances in its application. Bioengi...
KEY FINDING: Bioelectricity can be used to generate physiologically relevant CNS organoids for developmental studies and disease modeling, addressing the shortcomings of current protocols.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • January 1, 2023
The present study encapsulated activated Schwann cells (ASCs) in a 3D gelatin methacryloyl (GelMA) hydrogel in order to investigate its therapeutic effects on SCI. The scaffold was transplanted into t...
KEY FINDING: ASCs exhibited a favorable survival and proliferative ability in the 3D GelMA hydrogel.