Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 271-280 of 334 results
Genome Biology, 2024 • March 8, 2024
SpaDo is introduced as a computational framework for multi-slice spatial domain analysis, including multi-slice spatial domain detection, reference-based spatial domain annotation, and multi-slice clu...
KEY FINDING: SpaDo demonstrates good interpretability, robustness, and tolerance to noise and batch effects in spatial transcriptomic data analysis.
European Journal of Medical Research, 2024 • March 11, 2024
The study investigated COMP and ADAMTS7 as potential biomarkers for IVDD. Both animal and human studies showed that COMP and ADAMTS7 expression increased in tissues and serum during IVDD progression....
KEY FINDING: Serum COMP (sCOMP) and serum ADAMTS7 (sADAMTS7) levels increased in a time-dependent manner following IVD damage in the rabbit model.
Molecular Pain, 2024 • April 1, 2024
The study analyzed alternative splicing (AS) patterns in mouse brain, dorsal root ganglion (DRG), and spinal cord tissues under inflammatory and neuropathic pain conditions to understand the molecular ...
KEY FINDING: The study identified 6495 differentially alternatively spliced (DAS) genes in the mouse brain, dorsal root ganglion, and spinal cord tissue under inflammatory and neuropathic pain.
Cell Genomics, 2024 • May 8, 2024
Single-cell RNA sequencing (scRNA-seq) and T cell receptor sequencing (TCR-seq) are pivotal for investigating T cell heterogeneity. Herein, we present UniTCR, a novel low-resource-aware multimodal rep...
KEY FINDING: UniTCR enables detailed single-modality analysis by incorporating information from the other modality, offering a detailed understanding beyond what conventional single-modality approaches provide.
Genome Research, 2019 • March 1, 2019
This study presents a cost-effective approach to scaffolding the large axolotl genome and validates the resulting assembly using FISH and analysis of synteny conservation across vertebrates. The utili...
KEY FINDING: The study successfully assembled the axolotl genome into 14 chromosomes, covering 27.3 Gb and encompassing 94% of annotated gene models.
ACS Omega, 2024 • May 23, 2024
This study introduces AttFPGNN-MAML, a novel architecture for few-shot molecular property prediction that addresses the low data problem by incorporating a hybrid feature representation and leveraging...
KEY FINDING: The AttFPGNN-MAML method outperformed other methods on three out of four tasks in the MoleculeNet dataset, demonstrating superior performance in few-shot learning settings.
Metabolic Brain Disease, 2024 • July 9, 2024
This study used lipidomics and metabolomics to investigate lipid and metabolite changes in the spinal cords of diabetic rats with painful neuropathy. The results showed dysregulation of 170 metabolite...
KEY FINDING: Dysregulation of 170 metabolites and 45 lipids was observed in the spinal cords of rats with painful diabetic neuropathy (PDN).
iScience, 2024 • July 19, 2024
This theoretical study investigated whether the regeneration-inducing signal can follow a reaction-diffusion process, developing a computational model validated with experimental data. The study demon...
KEY FINDING: Spinal cord regeneration can be explained by a potential signaling mechanism operating under a reaction-diffusion scheme.
Bioinformatics, 2024 • July 18, 2024
SCRIPro is a computational framework designed to predict TR activity and reconstruct TR-centered GRNs for both single-cell and spatial multiomic data. SCRIPro addresses the challenge of sparse single-...
KEY FINDING: SCRIPro accurately reconstructs cell type-specific, stage-specific, and region-specific gene regulatory networks (GRNs).
Communications Biology, 2024 • December 2, 2024
The study provides a single-cell level atlas characterizing the tumor microenvironment (TME) in primary and recurrent multifocal bladder cancer (BLCA). Analyses reveal significant differences in malig...
KEY FINDING: Malignant cells from recurrent multifocal bladder cancer exhibited higher interregional transcriptional similarity and consistent cellular communication.