Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 281-290 of 334 results
Quant Imaging Med Surg, 2024 • April 10, 2024
The study validated an AI-based MAC algorithm for improving image quality in low-dose CT scans following percutaneous vertebroplasty (PVP). The AI-MAC algorithm demonstrated superior performance compa...
KEY FINDING: AI-MAC demonstrated no significant difference compared to reference images in CT attenuation, image noise, signal-to-noise ratios (SNRs), and contrast-to-noise ratio (CNR).
Nature Communications, 2024 • November 7, 2024
This study introduces CHOOSER, an AI framework for alignment-free discovery of CRISPR-Cas systems with self-processing pre-crRNA capability using protein foundation models. By using CHOOSER, the study...
KEY FINDING: CHOOSER identifies 3477 potential CRISPR-Cas systems, enhancing the number of known type II, type V, and type VI systems.
Nature Communications, 2025 • January 1, 2025
This document is an author correction for a previously published article in Nature Communications. The correction pertains to the affiliation details of one of the authors, Jun Zhang. The corrected af...
KEY FINDING: This is a correction to the author's affiliation; there are no key findings reported here.
Journal of Translational Medicine, 2025 • January 8, 2025
The study identifies key biomarkers related to ferroptosis and the immune microenvironment after SCI, providing clues for subsequent studies at the transcriptional and single-cell levels. WGCNA identi...
KEY FINDING: A novel subcluster of microglia exhibiting M1 polarization and a ferroptosis phenotype is involved in SCI, potentially triggering neuroinflammation and neuronal degeneration.
Scientific Data, 2025 • January 6, 2025
This study presents a comprehensive chromatin accessibility dataset of the rat nervous system using single-cell ATAC-seq, profiling 174,593 high-quality nuclei from 16 adult rat brain regions. The res...
KEY FINDING: Identified cell subtypes of both neuronal and non-neuronal cells with highly specific distributions in 16 adult rat brain regions.
Scientific Reports, 2025 • January 29, 2025
This study uses a transcriptomic approach to investigate the mechanisms by which photobiomodulation (PBM) exerts its effects on spinal cord injury (SCI) in rats. The findings indicate that PBM promote...
KEY FINDING: PBM treatment resulted in 1275 differentially expressed genes (DEGs), with 397 upregulated and 878 downregulated, indicating a significant change in gene expression patterns after PBM.
Journal of Translational Medicine, 2025 • January 1, 2025
This study provides a comprehensive transcriptomic meta-analysis of rat spinal cord injury (SCI) datasets, integrating diverse experimental models based on injury severity and time post-injury. The re...
KEY FINDING: The study identified severity-specific biomarker genes that allow precise classification of transcriptomic profiles, indicating potential for injury prognosis prediction.
Brain Res, 2015 • September 4, 2015
This review discusses the California Spinal Cord Consortium's (CSCC) work in developing a translational non-human primate model for spinal cord injury (SCI). The CSCC employs a biomedical informatics ...
KEY FINDING: The study highlights the development of a comprehensive preclinical data record for non-human primate SCI studies, including functional behavior, electrophysiology, kinematics, in vivo MRI, postmortem histopathology, and a full medical record.
BMC Genomics, 2015 • March 11, 2015
This study presents the first annotated de novo transcriptome assembly for Apteronotus leptorhynchus, offering a broad view of RNA expressed in the central nervous system. The assembly includes substa...
KEY FINDING: The de novo assembly uncovered 42,459 unique contigs containing at least a partial protein-coding sequence based on alignment to Actinopterygii sequences.
Nucleic Acids Research, 2015 • May 24, 2015
StemChecker is a web-based tool designed to help researchers discover and explore stemness signatures in gene sets. It addresses the limitations of existing resources by providing a comprehensive and ...
KEY FINDING: StemChecker is based on the most extensive and up-to-date curation of published stemness signatures.