Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 141-150 of 334 results
J Transl Med, 2020 • March 14, 2020
This study assessed factors associated with circulating PAMM levels in adults with acute, traumatic SCI and in adults without SCI. Factors associated with PAMM levels varied based on the presence or a...
KEY FINDING: Participants with motor complete SCI showed the greatest change in PAMM levels compared to able-bodied individuals, with a statistically significant difference.
Data in brief, 2020 • December 31, 2019
This data article describes RNA sequencing data for detecting chronic transcriptomic changes in the rat soleus after SCI at two levels of injury severity, under conditions of restricted in-cage activi...
KEY FINDING: The sequenced data demonstrates good quality with a high alignment rate to the Rattus norvegicus reference assembly (Rn6).
Spinal Cord, 2020 • April 8, 2020
This correction pertains to an error in a previously published article concerning the classification of participants with spinal cord injuries as either paraplegia or tetraplegia. The errors were pres...
KEY FINDING: The correction addresses an error in the naming of paraplegia and tetraplegia groups.
BMC Medical Research Methodology, 2020 • May 7, 2020
The paper introduces baseline-adjusted proportional odds models for analyzing ordinal outcomes in clinical trials, addressing limitations of conventional methods. A simulation study demonstrated the s...
KEY FINDING: The simulation study demonstrated that the statistical power of the novel method was greater than that of conventional methods.
Bioelectronic Medicine, 2020 • April 8, 2020
Computational models have significantly impacted neurostimulation, aiding in pain and movement recovery, deep brain stimulation, and device regulations. These models serve as virtual testing platforms...
KEY FINDING: Computational models have improved the understanding of direct neuromodulatory effects of deep brain stimulation (DBS), suggesting that DBS provides symptom relief by creating an informational lesion in the brain.
Stat Methods Med Res, 2020 • November 1, 2020
This paper develops cluster-weighted estimators of marginal proportions that remain unbiased under informativeness, and derives analogues of three popular tests for clustered categorical data: the one...
KEY FINDING: Cluster-weighted tests based on variance estimators constructed under the null hypothesis maintain size closest to nominal.
Biometrics, 2021 • June 1, 2021
The study proposes an adaptive method that tailors spinal cord stimulation devices to individual patient preferences. Batch Bayesian Optimization is used to balance exploration of the device configura...
KEY FINDING: Batch Bayesian optimization can be used to efficiently identify device configurations for long-term use with near-best patient preference.
Molecular Pain, 2020 • January 1, 2020
The study investigates the effects of different spinal cord stimulation (SCS) techniques on cell-specific transcriptomes in a rat model of neuropathic pain. It compares differential target multiplexed...
KEY FINDING: DTMP yielded strong and significant correlations to expression levels found in the healthy animals across every evaluated cell-specific transcriptome.
Journal of Personalized Medicine, 2020 • October 21, 2020
This study used a proteomic approach to understand the molecular mechanisms of COVID-19 infections in spinal cord injury (SCI) patients, aiming to identify biomarkers and potential therapeutic options...
KEY FINDING: Differentially expressed proteins were identified in SCI patients with COVID-19, with 20 proteins upregulated and 13 downregulated.
Journal of Personalized Medicine, 2020 • October 21, 2020
This study used a proteomic approach to identify biomarkers in blood plasma that could predict the response of patients with incomplete chronic traumatic spinal cord injury (SCI) to growth hormone (GH...
KEY FINDING: The combined treatment of GH plus rehabilitation is feasible and safe, and that GH but not placebo slightly improves the SCI individual motor score.