Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 131-140 of 334 results
Neuropsychopharmacology, 2022 • June 18, 2022
This study examined the association between day-of-injury blood biomarkers (GFAP and hsCRP) and the development of PTSD in patients with mild TBI. The results indicated that higher levels of GFAP were...
KEY FINDING: Elevated day-of-injury plasma GFAP levels were associated with a reduced risk of PTSD after mTBI.
Sensors, 2022 • June 20, 2022
This study introduces a multi-view vision based method for scoring the severity of Cervical Dystonia (CD). It addresses the need for remote diagnosis and treatment, especially highlighted by the recen...
KEY FINDING: The multi-view vision-based method demonstrated sufficient validity and reliability in scoring CD severity.
Cells, 2022 • July 18, 2022
This study used RNA sequencing to analyze gene expression changes in rats at five time points after spinal cord injury (SCI): 1 hour, 1 day, 1 week, 1 month, and 3 months. The researchers identified d...
KEY FINDING: The inflammatory response was increased at 1 hour and 1 day after SCI, while the integral component of the synaptic membrane was increased at 1 day.
PeerJ, 2022 • August 16, 2022
This study aimed to investigate the effect of Sema3A/NRP1 signaling in oligodendrocytes (OLs) after spinal cord injury (SCI) in rats. Bioinformatics analysis and experimental validation were used to e...
KEY FINDING: After SCI, significantly fewer oligodendrocytes were observed, while NRP1 and its ligand Sema3A were upregulated.
J Neural Eng., 2022 • October 18, 2022
This study introduces a machine-learning framework to identify EES parameters capable of generating desired patterns of EMG activity. The approach involves training a forward neural network model to p...
KEY FINDING: Neural networks can effectively approximate the complex computations of the spinal cord related to sensorimotor control, accurately predicting muscle activity based on EES parameters.
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
This study investigated the potential of muscle-based and circulatory biomarkers, specifically fatty metabolites and inflammatory cytokines, to predict pressure injury (PrI) recurrence in individuals ...
KEY FINDING: Gluteal intramuscular adipose tissue (IMAT) was greater than 15% in most Group II (83%) individuals, indicating a potential link between muscle quality and PrI recurrence.
Scientific Reports, 2019 • November 18, 2019
The study refines CMAP and MUNE methods for assessing spinal motor unit input in rat forelimbs and hindlimbs, demonstrating robustness and alignment with anatomical LMN counts. Validation in SOD1 muta...
KEY FINDING: CMAP and MUNE recordings are robust with low coefficients of variability in both forelimb and hindlimb of rats.
BMC Genomics, 2019 • November 8, 2019
This study aimed to elucidate the effect of α-Syn knockdown on transcriptional levels after SCI and to determine the mechanisms underlying α-Syn activity based on RNA-seq. RNA-seq analysis revealed 33...
KEY FINDING: Knockdown of α-Syn after SCI enhance motor function.
International Journal of Environmental Research and Public Health, 2020 • January 24, 2020
The paper introduces a concept for using big data analytics and sensor-enhanced activity management (SEAM) to improve outpatient medical rehabilitation. The proposed system aims to collect and analyze...
KEY FINDING: The project proposes a sensor-enhanced activity management (SEAM) approach, enabled by big data analytics (BDA), to improve outpatient rehabilitation effectiveness and efficiency for patients with neurological impairments.
Neuromodulation, 2021 • January 1, 2021
This study investigates the impact of spinal cord stimulation (SCS) on protein expression in the spinal cord of rats with neuropathic pain. The results showed that SCS leads to a significant improveme...
KEY FINDING: SCS significantly improved mechanical sensitivity in animals with neuropathic pain after 48 hours of therapy.