Browse the latest research summaries in the field of anesthesiology for spinal cord injury patients and caregivers.
Showing 11-20 of 46 results
Int. J. Mol. Sci., 2023 • February 28, 2023
This systematic review investigates spinal cord injuries (SCI) resulting from neuraxial anesthesia, aiming to identify high-risk patients and summarize causes, consequences, and management strategies....
KEY FINDING: The main risk factors for Anaes-SCI were extremes of age, obesity, and diabetes.
Current Neuropharmacology, 2023 • January 1, 2023
This study investigates the neurotoxic effects of bupivacaine, a local anesthetic commonly used in spinal anesthesia, on pregnant mice. The research aims to elucidate the underlying mechanisms, focusi...
KEY FINDING: Bupivacaine treatment in pregnant mice increases oxidative stress-mediated DNA damage and neuronal injury in the spinal cord.
Arq. Neuropsiquiatr., 2023 • April 14, 2023
The study investigates the effect of dexmedetomidine (DEX) on neuronal nitric oxide synthase (nNOS) expression in the spinal dorsal cord of rats with chronic neuropathic pain induced by sciatic nerve ...
KEY FINDING: TWL threshold decreased and nNOS expression increased in CCI and DEX groups compared to the sham group after the operation.
Molecular Pain, 2023 • January 1, 2023
This study investigates the preventive and therapeutic effects of a sub-anesthetic dose of propofol on chronic post-ischemic pain (CPIP) in mice, a model for complex regional pain syndrome (CRPS). The...
KEY FINDING: Propofol attenuates mechanical allodynia induced by CPIP in mice, both when administered pre-emptively and post-operatively.
Pharmacol Res Perspect, 2023 • July 1, 2023
The study investigated the anesthetic effects and spinal cord injuries in rats following intrathecal injection of levobupivacaine at varying concentrations. The results indicated that higher concentra...
KEY FINDING: Higher concentrations of intrathecal levobupivacaine resulted in shorter onset times and longer maintenance times for anesthesia in rats.
Cureus, 2023 • June 26, 2023
This case report describes the successful use of indigo carmine to manage catecholamine-refractory neurogenic shock in a 78-year-old woman with a cervical cord injury. The administration of indigo car...
KEY FINDING: Indigo carmine administration resulted in an immediate increase in systolic blood pressure from 60 mmHg to 130 mmHg in a patient with catecholamine-refractory neurogenic shock.
Anesthesiology, 2023 • December 1, 2023
The study characterized the neurochemical and electrophysiological phenotype of Oprm1-INs in the murine dorsal horn, revealing their contribution to neuropathic pain-like behavior. Peripheral nerve in...
KEY FINDING: Spared nerve injury (SNI) reduces Oprm1 gene expression and the responsiveness of Oprm1-INs to DAMGO, a selective μ agonist.
Int. J. Mol. Sci., 2023 • September 6, 2023
This study used a mouse chronic pain model to test the hypothesis that early exposure to the general anesthetic (GA) Isoflurane causes cellular and molecular alterations in dorsal spinal cord (DSC) and...
KEY FINDING: Early isoflurane exposure enhances sensitivity for mechanical and thermal stimuli in a chronic pain model caused by SNI.
Annals of Cardiac Anaesthesia, 2024 • January 12, 2024
This case report describes a rare instance of delayed paraparesis following coarctation of the aorta (CoA) repair, highlighting the potential for spinal cord injury (SCI) even in relatively straightfo...
KEY FINDING: The patient developed bilateral lower limb weakness on postoperative day 5, with MRI showing signs of ischemic insult to the cauda equina nerve roots.
Acta Clin Croat, 2023 • January 1, 2023
The case report presents a patient with SCIWOCTET who underwent cervical spine surgery. Airway management was achieved using a rigid bronchoscope with manual in-line immobilization to minimize cervica...
KEY FINDING: Rigid bronchoscopy with MILI allowed for successful intubation with minimal head and neck movement in a patient with SCIWOCTET.