Browse the latest research summaries in the field of alternative medicine for spinal cord injury patients and caregivers.
Showing 31-40 of 188 results
Immun Inflamm Dis, 2023 • June 19, 2023
This study demonstrates that Buyang Huanwu Decoction (BYHWD) can improve neurological recovery after traumatic spinal cord injury (SCI) in rats. The researchers used both in vivo and in vitro models t...
KEY FINDING: BYHWD suppresses apoptosis and accelerates cell proliferation after SCI, contributing to improved histological outcomes.
Journal of Orthopaedic Surgery and Research, 2023 • September 28, 2023
The study aimed to elucidate the mechanism of action of DHJSD on NP by identifying and analyzing active components, target genes and related signaling pathways, and validating the results in a CCI rat...
KEY FINDING: DHJSD treatment repaired the CCI-induced inflammatory reaction in the spinal cord while regulating the expression of ACHE, NOS2, MAPK3, PTGS2, AKT1, and PPARG mRNA.
Journal of Traditional Chinese Medicine, 2023 • August 2, 2023
The study evaluated the effects of berberine on morphine analgesia, tolerance, and hyperalgesia in mice, utilizing acute, chronic, and established morphine tolerance models. The researchers measured p...
KEY FINDING: Berberine can prolong the duration of morphine analgesia.
Pharmaceutics, 2023 • August 29, 2023
Salvianolic acid B, extracted from Danshen, exhibits diverse pharmacological effects, including antitumor, anti-inflammatory, antioxidant, and neuroprotective activities, making it a valuable compound...
KEY FINDING: Salvianolic acid B demonstrates antitumor effects by inducing apoptosis, autophagy, and oxidative stress, enhancing T cell activity, and inhibiting EMT and tumor cell proliferation across various cancers.
Immun Inflamm Dis, 2023 • September 5, 2023
This study revealed that the bioactive compound AF extracted from a peony (R. Paeoniae Alba) could efficiently improve motor function and reduce the loss of neuron cells in SCI rats. AF could reduce i...
KEY FINDING: Albiflorin (AF) administration alleviated motor dysfunction caused by acute SCI in a dose-dependent manner, improving the balancing ability of rats after acute SCI induction.
Heliyon, 2023 • October 4, 2023
This study investigates the efficacy and mechanism of Wuzi Yanzong Pill (WYP) in treating experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). The results demo...
KEY FINDING: WYP treatment significantly improved the clinical scores of EAE mice in a dose-dependent manner, indicating an improvement in neurological symptoms.
Chinese Medicine, 2023 • September 30, 2023
This review explores the neuroprotective properties of honokiol and its derivatives, focusing on their potential to treat neurological diseases like Alzheimer's, Parkinson's, and cerebral ischemia. Ho...
KEY FINDING: Honokiol activates SIRT3, demonstrating antioxidant properties and enhancing mitochondrial function, leading to a reduction in Aβ and sAPPβ levels in Alzheimer's disease models.
Medicine, 2023 • December 1, 2023
The study aimed to analyze the potential molecular mechanisms of action of VJJ in the treatment of SCI, using network pharmacology and molecular docking techniques. Key findings include the identifica...
KEY FINDING: Identified 56 active ingredients of VJJ, primarily iridoids, which are believed to be the main components responsible for its therapeutic effects.
Heliyon, 2024 • January 26, 2024
This study investigates the therapeutic effects and mechanisms of Sarsasapogenin (SA) against spinal cord injury (SCI) by integrating network pharmacology analysis and experimental verification. Netwo...
KEY FINDING: SA targets key proteins like TNF, RELA, JUN, MAPK14, and MAPK8, suggesting its potential to treat SCI by modulating inflammation-related signaling pathways.
Medicine, 2024 • February 1, 2024
This review uses network pharmacology and molecular docking to investigate the mechanisms of Zhenbao Pill (ZBP) in treating spinal cord injury (SCI). The study identifies key ingredients, targets, and...
KEY FINDING: ZBP contains 391 active ingredients and targets 836 proteins, with 1557 genes related to spinal cord injury.