Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint

Honokiol, found in Magnolia plants, has been used in traditional Chinese medicine for various conditions. Research suggests it may have anti-inflammatory, antioxidant, and neuroprotective effects, making it a potential treatment for neurological diseases. Honokiol can cross the blood-brain barrier and has shown neuroprotective properties in animal models of CNS disorders, like spinal cord injury and epilepsy, by preventing oxidative damage and neuroinflammation. Scientists are also studying honokiol derivatives to see if they can improve the drug's effectiveness and reduce potential side effects for treating neurological conditions.

• 1
  Honokiol activates SIRT3, demonstrating antioxidant properties and enhancing mitochondrial function, leading to a reduction in Aβ and sAPPβ levels in Alzheimer's disease models.
• 2
  Honokiol reduces motor deficits and neuronal degeneration in Parkinson's disease models by modulating NOS signaling and PPARγ.
• 3
  Honokiol has shown antidepressant and anti-anxiety properties, potentially by suppressing cytokine production and oxidative stress and increasing plasma BDNF levels.