Sarsasapogenin regulates the immune microenvironment through MAPK/NF-kB signaling pathway and promotes functional recovery after spinal cord injury

Spinal cord injury (SCI) results from damage to the spinal cord, leading to impaired motor, sensory, or autonomic functions. This study investigates Sarsasapogenin (SA), a natural compound, for its potential to treat SCI. The researchers used network pharmacology and experiments to understand how SA affects SCI. They found that SA targets key proteins and pathways involved in inflammation, suggesting it could help repair the spinal cord by modulating the immune environment. In experiments, SA improved functional recovery in rats with SCI and reduced inflammation by acting on the MAPK/NF-kB signaling pathways. This highlights the potential of SA, a natural compound from traditional Chinese medicine, as a treatment for SCI.

• 1
  SA targets key proteins like TNF, RELA, JUN, MAPK14, and MAPK8, suggesting its potential to treat SCI by modulating inflammation-related signaling pathways.
• 2
  In vivo experiments showed that SA has a reparative effect on SCI in rats, suggesting it can modulate the immune microenvironment to promote recovery.
• 3
  In vitro experiments demonstrated that SA regulates the immune microenvironment by inhibiting the MAPK/NF-kB pathways, further supporting its therapeutic potential for SCI.