Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 131-140 of 150 results
Front. Aging Neurosci., 2023 • August 2, 2023
This study investigates the role of leukotriene (LT) signaling in cognitive heterogeneity during aging, focusing on the expression of 5-lipoxygenase (5-Lox) and 5-lipoxygenase-activating protein (FLAP...
KEY FINDING: Expression of 5-Lox was increased within the brain of aged rats, with the highest levels detected in cognitively impaired animals, suggesting a link between the LT system and cognitive decline.
Aging Cell, 2023 • August 7, 2023
This study investigates the maturation of dormant neuronal precursors in the adult and aged brain using transgenic mice. The research questions whether the aging process affects the awakening and matu...
KEY FINDING: Dormant precursors can awaken and mature into adult-matured neurons (AM) even at old age, indicating that protracted immaturity does not prevent late awakening.
Frontiers in Endocrinology, 2023 • November 8, 2023
This study employed Mendelian randomization to investigate the causal relationship between sarcopenic obesity (SO) factors and benign prostatic hyperplasia (BPH), focusing on basal metabolic rate (BMR...
KEY FINDING: An increase in BMR is associated with an elevated risk of developing BPH.
International Journal of Biological Sciences, 2024 • January 1, 2024
This study demonstrates the depletion of the selective autophagy receptor NBR1 in NPCs during the degeneration process, leading to the buildup of SRBD1 within NPCs, thereby accelerating NPCs senescenc...
KEY FINDING: NBR1 expression is downregulated in degenerative nucleus pulposus cells (NPCs) in human and rat models of intervertebral disc degeneration (IDD).
Nature Communications, 2015 • October 27, 2015
The present work demonstrates that the anti-asthmatic drug and leukotriene receptor antagonist montelukast restores learning and memory function in old rats. Montelukast treatment reduced age-associat...
KEY FINDING: Montelukast treatment significantly improved task learning in old rats to a level comparable to young ones.
J. Clin. Med., 2024 • March 8, 2024
This meta-analysis provides the summary estimates for perioperative and postoperative functional outcome and safety of endoscopic treatment options for BPO in patients ≥75 years of age. Of particular ...
KEY FINDING: All surgical techniques significantly improve the postoperative quality of life of patients in this age group compared to their preoperative quality of life.
Nature Communications, 2024 • June 14, 2024
This study identifies dos-3 as a key gene mediating the cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of germline stem/progenitor cells (GSPCs) in C. elegans. DOS-3, a non-...
KEY FINDING: dos-3 encodes a non-canonical Notch ligand and is upregulated by DAF-16/FOXO activity in aging PSG cells of animals with reduced IIS.
Advanced Science, 2024 • June 19, 2024
This study reveals that CKB promotes mitochondrial ATP production by inhibiting AKT activation, which in turn reduces mitochondrial calcium levels and mPTP activity. The CKB-AKT signaling axis plays a...
KEY FINDING: CKB is essential for maintaining cellular sensitivity to F1F0 ATP synthase inhibition, a key enzyme in mitochondrial ATP production.
Frontiers in Physiology, 2015 • December 2, 2015
MSCs are considered promising for cell-based therapy due to their wide availability and resistance to malignant transformation. Despite progress, challenges remain in standardization, MSC-specific mar...
KEY FINDING: MSCs from older patients show reduced proliferative capacity, skewed differentiation potentials, telomere shortening, and DNA damage accumulation.
Brain, 2016 • January 29, 2016
Aging in the central nervous system (CNS) leads to a loss of gray and white matter, contributing to cognitive decline, which is further exacerbated by neurological disorders. This is accompanied by an...
KEY FINDING: Macrophages and microglia, two types of immune cells in the brain, age in distinct ways, with macrophages showing diminished pro-inflammatory responses and microglia exhibiting an exaggerated pro-inflammatory response with age.