Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 121-130 of 150 results
Neuroscience, 2013 • June 14, 2013
This study aimed to determine if short-term exercise alters GDNF protein content in the lumbar spinal cord of young and old rats. Different exercise protocols were tested. The results demonstrated tha...
KEY FINDING: Short-term exercise increases GDNF protein content in the lumbar spinal cord of both young and old rats.
Arch Phys Med Rehabil, 2014 • June 1, 2014
The study examined the additive effect of age on disability for adults with SCI using a prospective cohort study design. The results indicated that age at injury is associated with motor-FIM score, an...
KEY FINDING: Age at SCI was significantly associated with motor-FIM score, indicating that older individuals tend to have lower functional independence.
International Journal of MS Care, 2014 • January 1, 2014
Falls in MS are multifactorial and preventable, requiring knowledge of modifiable risks and theory-driven strategies. Research from outside MS, such as studies on older adults and spinal cord injury, ...
KEY FINDING: Age-related deterioration in visual, vestibular, and somatosensory systems can adversely affect postural control and contribute to falls in older people.
Molecules, 2021 • April 1, 2021
The study investigated the roles of GAL2-R and GAL3-R in learning, memory, and anxiety in young and aging mice. Knockout mice lacking either receptor were subjected to behavioral tests and analyses of...
KEY FINDING: Loss of GAL3-R, but not GAL2-R, slowed learning and induced anxiety in older (12–14-month-old) mice.
Oxidative Medicine and Cellular Longevity, 2022 • March 16, 2022
This study investigates the role of GIT1 in regulating axon growth within the inflammatory environment following spinal cord injury (SCI). The research found that GIT1 promotes axon growth by phosphor...
KEY FINDING: GIT1 knockout mouse neurons exhibited restricted axon growth in an inflammatory environment, highlighting GIT1's role in promoting growth under such conditions.
Aging and Disease, 2022 • April 1, 2022
This study investigates the role of CB2R in intervertebral disc degeneration (IVDD) by examining its effects on nucleus pulposus cell (NPC) senescence both in vitro and in vivo. The study found that C...
KEY FINDING: CB2R expression is decreased in degenerated nucleus pulposus (NP) tissues from both human IVDD patients and rat acupuncture IVDD models, while the expression of p16INK4a increased.
European Journal of Trauma and Emergency Surgery, 2022 • May 21, 2022
This retrospective cohort study aimed to differentiate geriatric odontoid fractures into stable (SFs) and unstable fractures (UFs) based on angulation and displacement, correlating this classification...
KEY FINDING: The classification into SFs and UFs was significant for its angulation (P = 0.0006) and displacement (P < 0.0001).
Neural Regeneration Research, 2023 • November 9, 2022
This study demonstrates that aging impairs neurological recovery and angiogenesis following spinal cord injury (SCI) in mice. Metformin, a common drug for type 2 diabetes, was found to promote angioge...
KEY FINDING: Aging hinders neurological function recovery and blood vessel formation in the spinal cord after injury.
Frontiers in Molecular Biosciences, 2023 • June 30, 2023
This study investigated platelet activation, proteome, and transcriptome in Alzheimer’s disease (AD) patients, non-demented elderly, and young individuals to understand the molecular mechanisms underl...
KEY FINDING: AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls.
Front. Cell. Neurosci., 2023 • July 28, 2023
This study investigates the age-related changes in cortical immature neurons (cINs) within the piriform cortex of mice, focusing on their numbers, morphology, and marker expression from postnatal stag...
KEY FINDING: The study found a significant decrease in the number of cINs in the piriform cortex as mice aged, particularly between 1 and 12-15 months.