Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 1-10 of 150 results
PLoS ONE, 2012 • December 7, 2012
This study used genome-scale transcriptional profiling to identify distinct age-dependent expression profiles in rat sensorimotor cortex during acute, subacute and chronic phases of spinal cord injury...
KEY FINDING: Aging significantly alters the cortical transcriptomes triggered by SCI, with little overlap in lesion-regulated genes between young and old animals.
Orthopaedic Surgery, 2025 • January 12, 2025
This study aimed to explore the role of aging and circadian rhythm-related genes in knee osteoarthritis (KOA). Differentially expressed genes (DEGs) were identified from the GEO database and intersect...
KEY FINDING: Identified 75 differentially expressed aging-circadian rhythm related genes between normal and KOA groups, primarily enriched in the circadian rhythm pathway.
Communications Biology, 2025 • January 7, 2025
This study provides a spatiotemporal atlas of young and aged spinal cord tissues using spatial transcriptomics, revealing changes in gene expression between grey and white matter regions. Integration ...
KEY FINDING: Bulk RNA sequencing identified 526 upregulated genes and 300 downregulated genes in senescent spinal cords compared to young spinal cords, with pathways related to phagosome function, neuroinflammation, ferroptosis, and necroptosis being enriched.
European Journal of Trauma and Emergency Surgery, 2025 • January 25, 2025
This study evaluated the predictive ability of various frailty scores for adverse outcomes in surgically managed isolated traumatic spinal injury (TSI) patients without spinal cord injury. Simpler fra...
KEY FINDING: The 5-mFI and 11-mFI outperformed other scores in predicting in-hospital mortality, any complication, and failure-to-rescue (FTR).
Irish Journal of Medical Science (1971 -), 2022 • September 19, 2022
The study analyzed data from a national tertiary referral center between 2016 and 2020, focusing on elderly patients (≥ 65 years) with traumatic cervical spine injuries and associated neurological def...
KEY FINDING: Complete SCIs are associated with increased length of stay, postoperative complications, life-threatening complications, and 90-day mortality compared to incomplete SCIs.
PLoS ONE, 2022 • November 17, 2022
This study aimed to identify the rate of physical restraint and associated risk factors among institutionalized residents in Taiwan. Data was collected from 5,752 residents across 266 institutions, fo...
KEY FINDING: 30.2% of the 5,752 institutionalized residents had been previously restrained.
J Trauma Acute Care Surg, 2023 • April 1, 2023
This retrospective study developed the Geriatric Interfacility Trauma Triage Score (GITTS) to improve secondary triage of injured older adults from non-tertiary to tertiary trauma centers. The GITTS m...
KEY FINDING: The Geriatric Interfacility Trauma Triage Score (GITTS) model, with an AUC of 75.4%, includes airway intervention, traffic-related femur fracture, spinal cord injury, ED GCS <=13, and hemodynamic support as the top predictors.
Tzu Chi Medical Journal, 2024 • May 24, 2024
Neurogenic lower urinary tract dysfunction (NLUTD) is common in patients with central nervous system (CNS) lesions, often leading to overactive bladder (OAB) symptoms and urinary incontinence. The rev...
KEY FINDING: Patients with CNS-related NLUTD commonly experience uninhibited detrusor overactivity, inadequate detrusor contractility, and dyscoordination of the urethral sphincter during voiding, which can lead to misdiagnosis and inappropriate treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • January 31, 2023
This study evaluated the clinical feasibility and efficacy of the Wiltse TTIF approach in elderly patients with single-segment thoracic tuberculosis complicated with osteoporosis and neurological dysf...
KEY FINDING: The study found that all 20 patients with SSTTB were completely cured without recurrence after undergoing Wiltse TTIF surgery combined with anti-TB chemotherapy.
Global Spine Journal, 2023 • January 1, 2023
This study evaluated surgical strategies for osteoporotic thoracolumbar fractures (OF 5) with anterior or posterior tension band failure, assessing complications and clinical outcomes. The results sho...
KEY FINDING: Surgical stabilization is an effective treatment for OF 5 fractures, leading to significant short-term improvements in functional outcome and quality of life.