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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 451-460 of 12,052 results

Spinal Cord InjuryImmunologyNeurology

Interleukin-3 Modulates Macrophage Phagocytic Activity and Promotes Spinal Cord Injury Repair

CNS Neuroscience & Therapeutics, 2024 • December 1, 2024

This study elucidates a crucial role of IL-3/IL-3Rα signaling pathway in modulating macrophages during the pathological progression of SCI. We observed a significant upregulation of IL-3, predominatel...

KEY FINDING: IL-3 expression was significantly upregulated post-SCI, peaking at 14 days post-injury (dpi) and persisting until 28 dpi. Notably, IL-3 was primarily secreted by astrocytes surrounding the lesion epicenter.

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OrthopedicsSpinal Disorders

Factors associated with postoperative coronal imbalance in adult patients with severe and rigid scoliosis: a retrospective study

Journal of Orthopaedic Surgery and Research, 2024 • December 1, 2024

This retrospective study analyzed 90 adult patients with severe rigid scoliosis (SRS) who underwent posterior column osteotomy (PCO) and fusion to identify risk factors for postoperative coronal imbal...

KEY FINDING: Preoperative coronal imbalance (CIB+) is significantly associated with postoperative CIB [OR = 12.414 (95% CI: 2.228, 69.162), P = 0.004].

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SurgeryOrthopedics

Analysis of Failed Posterior Fossa Decompression and an Effective Revision Surgery in Patients with Basilar Invagination and Atlantoaxial Dislocation

Orthopaedic Surgery, 2024 • December 1, 2024

This study analyzes the outcomes of patients with basilar invagination and atlantoaxial dislocation (BI-AAD) who underwent failed posterior fossa decompression (PFD) and introduces a novel revision su...

KEY FINDING: The revision surgery significantly improved the JOA and SF-12 scores one year after the operation, indicating better clinical symptoms and health status.

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Mental HealthGeneticsBrain Injury

Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

eClinicalMedicine, 2024 • December 1, 2024

This meta-analysis used data from the CENTER-TBI and TRACK-TBI studies to explore whether polygenic risk scores (PRS) for PTSD and major depressive disorder (MDD) are associated with the development o...

KEY FINDING: PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30–1.84, p < 0.001].

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Trauma

Assessment of the correlation between the Vittel criteria and the ISS score: A novel approach to pre-hospital severe trauma patient’s triage

LA TUNISIE MEDICALE, 2024 • December 1, 2024

The study evaluated the correlation between Vittel triage criteria and the Injury Severity Score (ISS) to improve pre-hospital triage accuracy. Seven key criteria were identified as independent predic...

KEY FINDING: Seven criteria were significantly associated with severe trauma (ISS >15): Glasgow Coma Scale<13, fall>6 m, severe burn, pelvic fracture, suspected spinal cord injury, Fluid resuscitation>1000 ml, Catecholamine.

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Alternative MedicinePharmacologyNeurology

Research progress on the role of ginsenoside Rd in central nervous system diseases

African Health Sciences, 2024 • December 1, 2024

This review summarizes the protective effects of Ginsenoside Rd (GSRd) in central nervous system diseases, highlighting its ability to cross the blood-brain barrier and its potential therapeutic appli...

KEY FINDING: Ginsenoside Rd (GSRd) has shown protective effects in neurological diseases such as ischemic stroke, spinal cord injury, Alzheimer's disease and Parkinson's disease.

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Spinal Cord InjuryPediatricsBrain Injury

Incidence and outcomes of pediatric patients with dual diagnosis of traumatic spinal cord injury and brain injury on an inpatient rehabilitation unit

PM&R, 2024 • December 1, 2024

This retrospective study aimed to determine the incidence and functional outcomes of pediatric patients with both traumatic brain injury (TBI) and spinal cord injury (SCI) on an inpatient rehabilitati...

KEY FINDING: The initial incidence of dual diagnosis (TBI and SCI) was 27%, but after a retrospective review, it was suggested that TBI may be underdiagnosed, potentially raising the incidence to 73%.

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Spinal Cord InjuryRehabilitationResearch Methodology & Design

Unveiling the mosaic: comparing demographics and outcomes in traumatic vs. non-traumatic spinal cord injuries

European Journal of Physical and Rehabilitation Medicine, 2024 • December 1, 2024

This study aimed to assess functional and neurological status at admission and discharge, identifying factors associated with outcomes in traumatic and nontraumatic SCI patients. The study revealed si...

KEY FINDING: Traumatic SCI patients were more often male, younger, and had more associated injuries.

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Spinal Cord InjuryRehabilitationSocial Support

Peer-supported interventions for people with spinal cord injury (Protocol)

Cochrane Database of Systematic Reviews, 2024 • December 1, 2024

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective: To assess the effects of peer-supported interventions on quality of life and self-management c...

KEY FINDING: The primary objective is to assess the effects of peer-supported interventions on quality of life and self-management compared to control groups in people with SCI.

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Alternative MedicineNeurologyRehabilitation

Efficacy of combined electroacupuncture and moxibustion for treatment of neurogenic bladder after spinal cord injury: A retrospective analysis

Medicine, 2024 • December 1, 2024

This retrospective study evaluated the clinical efficacy of combined electroacupuncture and moxibustion for the treatment of neurogenic bladder in patients with spinal cord injury. The study found tha...

KEY FINDING: The study group (electroacupuncture combined with moxibustion) showed significantly greater improvement in bladder function compared to the control group (electroacupuncture alone).

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