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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 431-440 of 12,052 results

Spinal Cord InjuryRegenerative MedicineBiomedical

Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair

Bioactive Materials, 2025 • December 6, 2024

This study presents a bioinspired conductive oriented nanofiber felt designed to treat complete spinal cord injury (SCI) by promoting neural regeneration and suppressing inflammation. The nanofiber fe...

KEY FINDING: The nanofiber felt promotes M2 macrophage polarization, reducing inflammation and oxidative stress.

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Spinal Cord InjuryBiomedical

Hyaluronidase-responsive hydrogel loaded with magnetic nanoparticles combined with external magnetic stimulation for spinal cord injury repair

Materials Today Bio, 2025 • December 6, 2024

This research presents a novel hydrogel system that responds to both hyaluronidase and external magnetic stimuli, designed for spinal cord injury (SCI) repair. The hydrogel, loaded with NGF and Fe3O4 ...

KEY FINDING: The novel hydrogel significantly promoted neural axon growth and development under an external magnetic field in cellular experiments.

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ImmunologyNeurologyPain Management

Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review

Frontiers in Immunology, 2024 • December 6, 2024

This scoping review characterizes the changes in spinal microglia over time in murine models of chronic pain. This study also evaluates the importance of the time points that different studies used to...

KEY FINDING: Most studies used inbred, young adult, male mice with peripheral nerve injury, limiting the generalizability of the data.

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Regenerative MedicineNeurologyGenetics

Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons

bioRxiv preprint, 2024 • December 6, 2024

The study investigates how different developmental origins shape the properties of V2a neurons, excitatory interneurons important for motor function, by differentiating them from hPSC-derived progenit...

KEY FINDING: Distinct progenitor origins (NEP vs. NMP) lead to differences in gene expression and chromatin accessibility in V2a neurons, even under identical differentiation conditions.

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Spinal Cord InjuryOrthopedicsRehabilitation

The Impact of Sports Training on the Spinal Cord Injury Individual’s Balance

Sensors, 2024 • December 6, 2024

This observational study assesses static balance in SCI individuals before and after a sports rehabilitation program, using clinical scales and optoelectronic motion tracking. The study demonstrates i...

KEY FINDING: The results demonstrate improvements in static balance, with significant reductions in sway length and mean velocity.

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Regenerative MedicineGeneticsBiomedical

Correction: Endothelial cell‑derived exosomes boost and maintain repair‑related phenotypes of Schwann cells via miR199‑5p to promote nerve regeneration

Journal of Nanobiotechnology, 2024 • December 6, 2024

This is a correction article for a paper published in the Journal of Nanobiotechnology. The correction addresses an error found in Figure 2D of the original publication. The corrected figure is includ...

KEY FINDING: An error was identified in the original article's Fig. 2D regarding the colony formation of Schwann cells in the EXO-1 μg/mL group.

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Regenerative MedicineNeurology

Granulocyte colony-stimulating factor promotes regeneration of severed facial nerve in rats

Frontiers in Neuroscience, 2024 • December 5, 2024

This study investigates the effects of granulocyte colony-stimulating factor (G-CSF) on facial nerve regeneration in rats with either resected or severed-and-sutured facial nerves. The study found tha...

KEY FINDING: Recovery of damaged facial nerves was faster in rats whose severed nerves were sutured compared to those with partially resected nerves.

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Spinal Cord InjuryNeurology

DBS in the restoration of motor functional recovery following spinal cord injury

Frontiers in Neurology, 2024 • December 4, 2024

This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. Advances in techniques lik...

KEY FINDING: DBS targeting specific brain regions like the mesencephalic locomotor region (MLR), cuneiform nucleus (CNF), and nucleus raphe magnus (NRG) shows promise for motor functional recovery after SCI.

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Spinal Cord InjuryNeurologyRehabilitation

Spinally targeted paired associative stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects

Scientific Reports, 2024 • December 4, 2024

This study investigates the effects of spinally and cortically targeted high-frequency paired associative stimulation (high-PAS) on spinal level plasticity in healthy subjects. The results indicate th...

KEY FINDING: MEPs were significantly enhanced in both spinally and cortically targeted interventions, indicating increased corticospinal excitability.

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Spinal Cord InjuryNeurologyVeterinary Medicine

Characterization of risk factors for early ambulation in paraplegic dogs with absent pain perception undergoing decompressive surgery for thoracolumbar intervertebral disk extrusions

Frontiers in Veterinary Science, 2024 • December 4, 2024

This study aimed to characterize early ambulation, identify risk factors for return of ambulation, and compare the outcome of French bulldogs compared to Dachshunds following TL-IVDE surgery. The stud...

KEY FINDING: Approximately 60.6% of dogs regained the ability to walk after surgery, and 7.1% regained walking ability without regaining pain sensation.

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