Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,981-3,990 of 12,052 results
Nucleic Acids Research, 2022 • September 26, 2022
The study introduces SCRIP, a computational method for inferring single-cell gene regulation networks by integrating scATAC-seq data with a large-scale ChIP-seq reference. SCRIP evaluates TR activity ...
KEY FINDING: SCRIP shows improved performance in evaluating TR binding activity compared to motif-based methods, with higher consistency with matched TR expressions.
Int. J. Mol. Sci., 2022 • September 26, 2022
This review discusses the potential connection between ALS-related genes/proteins and neuroregeneration and development, particularly focusing on the timing when neuroregeneration ceases. The authors ...
KEY FINDING: Fifteen risk loci with distinct genetic architectures and neuron-specific biology were identified as linked to ALS.
Journal of Nanobiotechnology, 2022 • September 25, 2022
This study introduces a GelMA-MXene hydrogel nerve conduit with microgrooves for spinal cord injury (SCI) repair, capitalizing on the electrical conductivity of MXene and the cell-guiding properties o...
KEY FINDING: The grooved GelMA-MXene hydrogel promotes neural stem cell adhesion, proliferation, and differentiation in vitro.
Int. J. Mol. Sci., 2022 • September 24, 2022
This study investigates the role of AhR in neuropathic pain using nerve explant cultures and a CCI model in mice. The findings suggest that AhR agonists could be potential candidates for neuropathic p...
KEY FINDING: Deletion of AhR aggravated nerve damages and this was restored by omeprazole, indicating a protective role of AhR in nerve health.
PLOS ONE, 2022 • September 23, 2022
This study aimed to determine if receiving opioids in the emergency department (ED) after a traumatic injury is associated with subsequent at-risk opioid use within three months. The researchers analy...
KEY FINDING: ED opioid exposure, whether through prescription or administration, is associated with a higher likelihood of at-risk opioid use within three months after a traumatic event.
Nature Communications, 2022 • September 23, 2022
The study presents a single-cell atlas of the lumbar spinal cord after thoracic spinal cord injury in mice, detailing cell type-specific responses across acute, subacute, and chronic stages. The resea...
KEY FINDING: Rare spinal neurons, particularly spinocerebellar projection neurons, express a signature of regeneration in response to spinal cord injury.
Frontiers in Cellular Neuroscience, 2022 • September 23, 2022
This review discusses the current research on m6A modification and its relationship with pathophysiological processes after SCI, including cell death, axonal regeneration, and scarring. Research on th...
KEY FINDING: m6A modification levels change after spinal cord injury (SCI), and m6A-related regulators are involved in the changes of the local spinal cord microenvironment after injury.
Biomedicines, 2022 • September 21, 2022
This study used a rat model of spinal cord injury (SCI) induced by cryoinjury to evaluate histological, bioimaging, and cytokine data. The goal was to find noninvasive methods for evaluating the thera...
KEY FINDING: Plasma levels of IL-1α, IL-1β, TNFα, GRO/KC, G-CSF, IFNγ and IL-13 may be considered as a reliable prognostic index for SCI.
Frontiers in Neuroscience, 2022 • September 20, 2022
This systematic review investigated the neuroinflammatory effects of PBM therapy in animal models of brain pathological conditions. The reviewed studies showed that the therapeutic effects of transcra...
KEY FINDING: PBM reduces pro-inflammatory cytokines and microglia activation in traumatic brain injury animal models.
Frontiers in Rehabilitation Sciences, 2022 • September 20, 2022
This editorial discusses the importance of community reintegration for individuals with spinal cord injuries (SCI). It highlights the shift in rehabilitation towards a biopsychosocial model that addre...
KEY FINDING: A longitudinal study showed that within the first year following SCI, 55% of participants struggled with social participation, and only one third were employed.