Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,921-3,930 of 12,052 results
Journal of Neuroinflammation, 2022 • October 4, 2022
This study investigates the effect of SAFit2 on nerve injury-induced neuropathic pain in mice. The findings indicate that SAFit2 reduces neuroinflammation and ameliorates mechanical hypersensitivity. ...
KEY FINDING: SAFit2 ameliorates nerve injury-induced neuropathic pain by reducing neuroinflammation.
J. Clin. Med., 2022 • October 4, 2022
This retrospective study assessed the long-term satisfaction and complications of various urinary incontinence treatments in 700 chronic SCI patients. The goal was to determine which bladder managemen...
KEY FINDING: High satisfaction rates were observed after detrusor Botox injection (81.1%), augmentation enterocystoplasty (91.4%), autoaugmentation (80%), Kock pouch diversion, and continent cystostomy (all 100%).
J. Clin. Med, 2022 • October 4, 2022
This study evaluated the length of vertebral fusion as a potential indicator for reduced rehabilitation success in individuals suffering from cervical spinal cord injury. The length of fusion, SCIM at...
KEY FINDING: Cervical fusion length was identified as an independent predictor of functional outcome, as measured by the Spinal Cord Independence Measure II (SCIM II).
Int. J. Mol. Sci., 2022 • October 4, 2022
This study evaluated the therapeutic potential of a selective calpain inhibitor (PD150606) in combination with methylprednisolone sodium succinate (MPSS) in a dog SCI model. The findings revealed that...
KEY FINDING: The combined administration of MPSS+PD150606 demonstrated considerably lower neuronal loss and microglial cell infiltration than the other groups, with a significant improvement in the locomotor score.
Journal of Orthopaedic Surgery and Research, 2022 • October 4, 2022
The study aimed to develop a prediction model for functional outcomes in acute SCI patients using XGBoost. The XGBoost model, incorporating clinical features, MR imaging, and surgical timing, outperfo...
KEY FINDING: A nonlinear regression prediction model was successfully constructed using XGBoost for patients with acute SCI.
Disease Markers, 2022 • October 4, 2022
This work provides a systems perspective to study the relationship between Chinese medicines and diseases. The therapeutic efficacy of XCHD on HF was the sum of multitarget and multi-approach effects fro...
KEY FINDING: 164 potential active compounds from XCHD were screened to act on 95 HF-related targets.
Genome Biology, 2022 • October 4, 2022
This study presents a comprehensive evaluation of cell-cell interaction tools for scRNA-seq data by integrating spatial information to benchmark their performance. The spatial distance between interac...
KEY FINDING: The study found that cell-cell interactions predicted by different tools are highly dynamic, suggesting variability in the methods' outputs.
Mediators of Inflammation, 2022 • October 3, 2022
This study investigated the role of IL-1β in spinal cord contusion and its impact on motor function recovery. The research found that inhibiting IL-1β expression promotes motor function recovery after...
KEY FINDING: IL-1β expression increases in spinal cord tissue after SCC and hinders motor function recovery.
Nature Communications, 2022 • October 3, 2022
This study investigates the influence of lesion environments on the fate of transplanted neural progenitor cells (NPCs) in mice. NPCs were transplanted into either uninjured CNS or subacute CNS lesion...
KEY FINDING: NPCs transplanted into uninjured CNS differentiate into cells transcriptionally similar to healthy astrocytes and oligodendrocytes.
J Neurosurg Case Lessons, 2022 • October 3, 2022
This case report presents a 16-year-old male with asymmetrical neurological deficits following a traumatic cervical spinal cord injury who underwent simultaneous bilateral nerve transfers to restore p...
KEY FINDING: Following nerve transfers, the patient regained M4 strength in the long head of the triceps brachii bilaterally, indicating successful restoration of elbow extension.