Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,911-3,920 of 12,052 results
Frontiers in Rehabilitation Sciences, 2022 • October 6, 2022
This study implemented a pre-visit Pandemic Intake questionnaire to assess the impact of COVID-19 on patients with neurodevelopmental disorders at the Kennedy Krieger Institute. The questionnaire iden...
KEY FINDING: Guardians of patients in more medically complicated clinics reported a perceived increased risk of COVID-19 and difficulty obtaining therapies and surgeries.
PLoS ONE, 2022 • October 5, 2022
This study compared four recompression treatment tables (TT6, TT6A-air, TT6A-nitrox, TT6A-heliox) for neurologic decompression illness (DCI) in a swine model. The primary outcome was the mean number o...
KEY FINDING: No significant differences were found in functional neurologic outcomes among the four treatment groups (TT6, TT6A-air, TT6A-nitrox, and TT6A-heliox) or between the two treatment profiles (TT6 and TT6A).
Frontiers in Immunology, 2022 • October 5, 2022
This study identifies and characterizes aging/senescence-induced genes (ASIGs) in osteosarcoma to predict clinical prognosis. The researchers used data from public databases to identify three molecula...
KEY FINDING: The study identified three distinct molecular subgroups of osteosarcoma based on the expression of aging/senescence-induced genes (ASIGs), each exhibiting varying levels of immune infiltration.
Frontiers in Pharmacology, 2022 • October 5, 2022
Spinal cord injury (SCI) is a devastating condition with limited effective treatments. Oxidative stress (OS) significantly contributes to secondary injury mechanisms following SCI. Traditional Chinese...
KEY FINDING: Oxidative stress plays a vital role in secondary injury after SCI, leading to damage of biological macromolecules, ion imbalances, and mitochondrial dysfunctions.
Frontiers in Neuroscience, 2022 • October 5, 2022
This systematic review and network meta-analysis of EVs derived from miRNA-modified MSCs for the treatment of SCI included data from 13 preclinical trials among a total of 396 rats. The results of this...
KEY FINDING: miRNA-overexpressing MSCs-derived EVs (100 and 200 µg of total protein of EVs) significantly improved hind limb motor function in rats at early stages of SCI (i.e., at 3 days after injury) as compared with EVs (100 and 200 µg of total protein of EVs, respectively).
Frontiers in Pharmacology, 2022 • October 5, 2022
The study analyzed peripheral blood RNA-seq samples from SCI patients and healthy controls to identify key differentially expressed genes and construct a diagnostic model. In vitro experiments demonst...
KEY FINDING: Peripheral blood transcriptome is altered after SCI, reflecting similar negative effects as neuronal damage at the lesion site.
Curr. Oncol., 2022 • October 5, 2022
This retrospective study compared urgent surgery followed by radiotherapy (USFR) to urgent radiotherapy alone for treating acute metastatic spinal cord compression (AMSCC). The results indicated that ...
KEY FINDING: Patients treated with urgent surgery followed by radiotherapy (USFR) showed significant improvement in motor strength compared to those treated with radiotherapy alone.
Asian Spine J, 2022 • October 5, 2022
Accurate diagnosis and patient-specific treatment strategies for spinal diseases are of paramount importance although remain challenging despite the advancement of diagnostic technologies. In recent y...
KEY FINDING: Plain radiography is the first and most widely used imaging modality for localizing suspected spinal symptoms, including pain, numbness, and weakness.
Frontiers in Rehabilitation Sciences, 2022 • October 5, 2022
This review discusses the utility of transcranial magnetic stimulation (TMS) in assessing spinal cord injury (SCI). It highlights how TMS can supplement clinical assessments by providing objective neu...
KEY FINDING: TMS can detect residual corticomotor connectivity after SCI, even when clinical assessments indicate a complete injury, which can help identify 'discomplete' SCI and potentially guide rehabilitation strategies.
Nature Communications, 2022 • October 4, 2022
The study investigates the role of the alarmin IL-1α in spinal cord injury (SCI). IL-1α, primarily derived from damaged microglia, triggers a cascade of events leading to oligodendrocyte (OL) death, i...
KEY FINDING: Microglia-derived IL-1α induces OL death through the astrocytic and endothelial IL-1R1.