Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 311-320 of 12,052 results
Child's Nervous System, 2025 • January 1, 2025
The study retrospectively reviewed patients who underwent myelomeningocele/myeloschisis closure between 2013 and 2018, following them up to 5 years of age to evaluate cystic spinal lesions. The findin...
KEY FINDING: Cystic lesions are common after myelomeningocele/myeloschisis closure, with 51.2% of patients developing radiographic evidence of cysts.
eNeuro, 2025 • January 1, 2025
The study investigated TrkB signaling in DRG neurons as a potential neural mechanism that underlies pain hypersensitivity after SCI. The results revealed that TrkB-mediated inward current and its prot...
KEY FINDING: SCI decreased 7,8-DHF-induced current while increasing the latency to its peak amplitude.
Scand J Trauma Resusc Emerg Med, 2025 • January 1, 2025
This consensus statement introduces a new approach to extrication, prioritizing time-sensitive and patient-centered care over strict movement minimization. The recommendations advocate for empowering ...
KEY FINDING: Self-extrication is now considered the preferred initial approach when appropriate.
Journal of Central Nervous System Disease, 2025 • January 1, 2025
This report demonstrated the potential value of transforming grayscale MRI images into color, visually enhancing the anatomical data and possibly providing more information that may inform on the impa...
KEY FINDING: The transformation of grayscale MRI FLAIR images to color via generative AI revealed heterogeneity in the T2-hyperintensities present with some of the lesions having a more yellow appearance and others appearing more white in color
Cell Biol Toxicol, 2025 • January 1, 2025
This study investigates the effect of Comp 6d, a novel SIRT1 activator, on neuropathic pain and explores its mechanisms. The findings suggest that Comp 6d alleviates neuropathic pain by specifically a...
KEY FINDING: Comp 6d alleviates neuropathic pain by specifically activating SIRT1 in the spinal cord, as demonstrated by the abolishment of its effects in SIRT1 knockout mice.
Immunity, Inflammation and Disease, 2025 • January 1, 2025
This study investigates the potential of Isosteviol sodium (STVNa) to promote neurological function recovery in a rat model of spinal cord injury (SCI). The results demonstrate that STVNa improves loc...
KEY FINDING: STVNa improved spinal cord functional recovery in rats, evidenced by enhanced BBB locomotor rating scale and angle of inclination.
Journal of Nanobiotechnology, 2025 • January 1, 2025
This study investigates the effects of Apelin-13, delivered via a ROS-responsive hydrogel, on macrophage polarization and neuroinflammation in a rat model of spinal cord injury (SCI). The hydrogel was...
KEY FINDING: Apelin-13 is significantly downregulated in the injured sites of the SCI model rats since day 14 after modeling.
Acta Cir Bras, 2025 • January 1, 2025
This study aimed to investigate the neuroprotective role of gallic acid on spinal cord tissues after spinal cord injury (SCI) and its relationship with endoplasmic reticulum (ER) stress. The results s...
KEY FINDING: Histological analysis showed that gallic acid improved neural cell survival and tissue integrity in rats with spinal cord injury.
Scientific Reports, 2025 • January 1, 2025
This study used CT scans of 160 Emirati patients to determine the optimal screw dimensions, entry points, bony corridors, and screw trajectories for C1 lateral mass screw placement. The research ident...
KEY FINDING: The study found that a screw entry at the center of the lateral mass, below its junction with the posterior arch, allowed straight screws of lengths 20 mm and 19.5 mm in Emirati males and females, respectively.
Journal of Nanobiotechnology, 2025 • January 1, 2025
This study synthesized ultra-small LNT-UsSeNPs, demonstrating improved therapeutic effects against SCI due to enhanced structural design and surface modifications with LNT to improve stability and cel...
KEY FINDING: LNT-UsSeNPs exhibit superior ROS scavenging capabilities compared to conventional LNT-SeNPs, protecting PC-12 cells from oxidative stress-induced cytotoxicity and alleviating mitochondrial dysfunction.