Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea: A cross-sectional case–control study

J Eur Acad Dermatol Venereol, 2025 · DOI: 10.1111/jdv.19954 · Published: January 1, 2025

Simple Explanation

Rosacea is a common skin condition that causes redness and bumps on the face. Researchers are trying to understand what causes it, including the role of a molecule called CGRP. Capsaicin, the ingredient that makes chili peppers hot, can trigger rosacea. It increases blood flow by activating channels and releasing CGRP. This study found that people with rosacea have higher levels of CGRP in their blood compared to healthy individuals, suggesting CGRP may play a role in rosacea.

Study Duration

Not specified

Participants

123 individuals with rosacea and 68 healthy controls

Evidence Level

Cross-sectional case–control study

Key Findings

1
Plasma levels of CGRP were significantly higher in individuals with rosacea compared to healthy controls after adjusting for age and sex.
2
No significant associations were found between CGRP levels and rosacea severity or specific rosacea subtypes.
3
A slightly negative association was found between rosacea duration and plasma CGRP levels.

Research Summary

The study investigated plasma levels of CGRP in individuals with rosacea and healthy controls to understand CGRP's role in rosacea pathogenesis. The results showed elevated plasma levels of CGRP in individuals with rosacea compared to healthy controls, suggesting a potential role of CGRP in the pathophysiology of rosacea. The study suggests that treatments targeting CGRP signaling could be beneficial in managing rosacea, warranting further research.

Practical Implications

Therapeutic Target

Targeting CGRP signaling might hold therapeutic promise in people affected by rosacea.

Early Intervention

The negative association between CGRP levels and rosacea duration suggests early intervention might be important.

Further Research

Further research is needed to investigate the potential of medications targeting CGRP signaling in managing rosacea.

Study Limitations

1
Participants were not age-, sex- and BMI-matched.
2
Individuals with rosacea often having coexisting migraine which is a possible confounder.
3
Data on age-related CGRP level changes in healthy group are incomplete.

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