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  4. Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training

Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training

Frontiers in Human Neuroscience, 2025 · DOI: 10.3389/fnhum.2024.1502517 · Published: January 14, 2025

Spinal Cord InjuryNeurologyRehabilitation

Simple Explanation

This study explores using robot-assisted training that involves both hands to help someone with a spinal cord injury improve their arm and hand function. The training aimed to improve movement and daily living activities. The patient underwent 20 training sessions, and researchers monitored brain activity using EEG to see how the brain changed in response to the training. The study looked at how well the patient could move their arms, perform daily tasks, and changes in brain activity related to movement. The results showed that the patient's arm function and independence improved after the training. Brain activity patterns also changed, suggesting that the training helped the brain reorganize itself to improve motor function.

Study Duration
20 days
Participants
One 29-year-old male with incomplete cervical SCI
Evidence Level
Level 4; Case Report

Key Findings

  • 1
    Robot-assisted bimanual training (RBMT) improved the patient’s upper limb motor function and activity independence.
  • 2
    The ERD pattern shifted from being predominantly ipsilateral to a contralateral allocation following the RBMT.
  • 3
    Motor function improved in parallel with the changes in ERD pattern over time indicates a possible relationship between mu-ERD and upper limb function.

Research Summary

This case study investigated the effects of robot-assisted task-oriented bimanual training (RBMT) on upper limb function, activities of daily living, and movement-related sensorimotor activity in a patient with SCI. RBMT improved the patient’s upper limb motor function and activity independence. Following the RBMT, the ERD pattern shifted from being predominantly ipsilateral to a contralateral allocation. The study provides preliminary evidence to support the therapeutic use of RBMT to restore upper limb function in patients with incomplete SCI, and the recovery of function following SCI might be related to the rebalancing of sensorimotor activation.

Practical Implications

Rehabilitation Strategy

RBMT can be considered as a potential therapeutic intervention to improve upper limb function in patients with incomplete SCI.

Neuroplasticity

The study highlights the role of neuroplasticity and sensorimotor rebalancing in motor recovery after SCI.

Further Research

The findings suggest the need for further studies to validate the effectiveness of RBMT in a larger population and to explore the underlying mechanisms of functional improvements.

Study Limitations

  • 1
    Assessed only one participant, limiting generalizability.
  • 2
    Selected tasks in RBMT are not centered on ADL.
  • 3
    RBMT is designed for hemiplegia initially.

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