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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 121-130 of 12,052 results

Spinal Cord InjuryNeurologyGastroenterology

Fecal microbiota transplantation promotes functional recovery in mice with spinal cord injury by modulating the spinal cord microenvironment

Journal of Translational Medicine, 2025 • February 11, 2025

This study investigated the effects of fecal microbiota transplantation (FMT) on motor function recovery in a spinal cord injury (SCI) mouse model. The results demonstrated that FMT restored gut micro...

KEY FINDING: FMT significantly improved motor function recovery in SCI mice compared to those treated with antibiotics alone, as shown by BMS scoring, inclined plane test, and footprint analysis.

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Spinal Cord InjuryRegenerative MedicineBiomedical

Research Progress on Biomaterials for Spinal Cord Repair

International Journal of Nanomedicine, 2025 • February 11, 2025

This review summarizes the current research status of the application of biomaterials to the SCI treatment, in recent years, to provide some comprehensive information and reference value for future ex...

KEY FINDING: Biomaterial scaffolds can be used for drug delivery, cell load, and tissue engineering to facilitate the repair of SCIs, while acting as a scaffold and microenvironment for tissue growth with reduced inflammatory responses.

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Spinal Cord InjuryAlternative MedicineNeurology

Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2‑Mediated cAMP‑PKA Signaling in the Spinal Cord Microenvironment

Cellular and Molecular Neurobiology, 2025 • February 11, 2025

This study investigated the effects of electroacupuncture (EA) on spinal cord injury (SCI) in rats, focusing on the role of urocortin 2 (UCN2) and the cAMP-PKA signaling pathway. EA treatment improved...

KEY FINDING: EA treatment significantly improved behavioral scores and hind-limb locomotion in rats with SCI at 7, 14, and 28 days post-injury.

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Spinal Cord InjuryRegenerative MedicineImmunology

Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Stem Cells Translational Medicine, 2025 • February 11, 2025

The study investigates how different immunomodulatory strategies (genetic immunodeficiency vs. pharmacological immunosuppression) affect the survival, integration, and gene expression of transplanted ...

KEY FINDING: X-SCID rats exhibited significantly higher retention of transplanted NPCs compared to both Wistar and RNU rats, indicating that both T and B cells play crucial roles in the rejection of xenografted human NPCs.

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AccessibilityDisability

Identifying priorities and developing collaborative action plans to improve accessible housing practice, policy, and research in Canada

PLoS ONE, 2025 • February 10, 2025

This article describes the development of priorities and actions to improve the state of research, policy, and practice related to accessible housing in Canada for persons with disability or with acce...

KEY FINDING: The expert panel identified three clusters of priorities: engaging with all levels of government to support accessible housing efforts.

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Spinal Cord InjuryNeurologyRehabilitation

Development of a functional electrical stimulation cycling toolkit for spinal cord injury rehabilitation in acute care hospitals: A participatory action approach

PLOS ONE, 2025 • February 10, 2025

The study developed a toolkit to facilitate the implementation of FES cycling for individuals with a newly acquired spinal cord injury (SCI) in acute care inpatient hospital settings. Participatory ac...

KEY FINDING: Four main themes were identified: healthcare provider toolkit content and categories, healthcare provider toolkit end product, collaborations between groups and institutions, and infrastructure.

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ImmunologyOrthopedicsSpinal Disorders

Modified posterior vertebral column resection for extremely severe post-tubercular kyphosis in adults: a two-year follow-up

Journal of Orthopaedic Surgery and Research, 2025 • February 10, 2025

This study retrospectively analyzed 22 patients with severe post-tubercular kyphosis (PTK) who underwent modified posterior vertebral column resection (mPVCR). The results demonstrated significant imp...

KEY FINDING: The modified PVCR technique resulted in a significant improvement in kyphosis angle (KA) from 129.5° to 43.7° postoperatively.

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Spinal Cord InjuryNeurologySpinal Disorders

Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia

Fluids and Barriers of the CNS, 2025 • February 10, 2025

This study investigates the role of ependymal cilia and AQP4 in syringomyelia using a rat model. The findings highlight the significance of cilia on ependymal cells and the evolving microenvironment p...

KEY FINDING: Ependymal cilia are significantly reduced in syringomyelia, with altered morphology, and cell junctions between ependymal cells are loose and broken.

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NeurologyPain ManagementResearch Methodology & Design

The role of glial cells in neuralgia: a bibliometric exploration

Frontiers in Neurology, 2025 • February 7, 2025

This study employs bibliometric analysis to explore trends and emerging hotspots in research on the relationship between glial cells and neuropathic pain. Based on literature data from the Web of Scie...

KEY FINDING: China and the United States are the leading countries in research on glial cells and neuropathic pain, with the University of California system being the top institution.

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Spinal Cord InjuryRegenerative Medicine

Stem cell therapies for spinal cord injury in humans: A review of recent clinical research

Brain and Spine, 2025 • February 7, 2025

This review provides an overview of recent advances in cell transplantation therapy, focusing on patients involved in clinical research. Over the past decade, numerous clinical studies of SCI have bee...

KEY FINDING: Promising results have been reported for patients with subacute SCI, especially in studies involving MSCs, such as those conducted with Stemirac, although no universally recognized breakthroughs have been achieved.

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