Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 12,031-12,040 of 12,052 results
CMLS, Cell. Mol. Life Sci., 2004 • January 19, 2004
This study investigates the mechanisms by which olfactory ensheathing cells (OECs) promote axonal regeneration using an in vitro model of axonal injury. The findings indicate that OECs promote neurite...
KEY FINDING: OECs promote neurite sprouting after injury by acting as a physical substrate for growth.
The Journal of Neuroscience, 2004 • January 14, 2004
This study examined the role of p75NTR in spinal cord regeneration using p75NTR-deficient mice and a p75NTR-Fc fusion molecule. The results showed that neither the deletion of p75NTR nor the administr...
KEY FINDING: p75NTR immunoreactivity was observed in the dorsal horn and medial part of the dorsal column, but not in the CST of normal mice.
Annu Rev Med, 2004 • January 1, 2004
The prospects for successful clinical trials of neuroprotective and neurorestorative interventions for patients with acute and chronic myelopathies depend on preclinical animal models of injury and re...
KEY FINDING: Neurotrophic factors, such as BDNF, can reverse atrophy of rubrospinal neurons and promote spinal axon regeneration, even when administered long after SCI.
IEEE Trans Neural Syst Rehabil Eng, 2003 • December 1, 2003
This study investigates the impact of foot placement on postural control during reaching tasks, particularly for individuals with spinal cord injuries using functional neuromuscular stimulation (FNS)....
KEY FINDING: The modified tandem stance led to larger and more consistent anterior/posterior COP excursions across different reach directions compared to side-by-side and wide stances.
J Neurophysiol, 2003 • October 1, 2003
This study examines the expression and function of PACAP in the olfactory system of mice and rats, finding it present in olfactory epithelium and olfactory ensheathing cells. The study highlights diff...
KEY FINDING: PACAP immunoreactivity is present in the olfactory epithelium of neonatal, adult mice, and adult rats.
Eur Spine J, 2004 • August 14, 2003
This technical note presents a minimally invasive technique using topical rt-PA for evacuating extensive spinal subdural haematomas in two patients on long-term anticoagulation therapy. The technique ...
KEY FINDING: Topical application of rt-PA allows evacuation of the haematoma through a limited surgical exposure.
PNAS, 2003 • July 22, 2003
This study investigates the impact of glial fibrillary acidic protein (GFAP) and vimentin deficiency on axonal plasticity and functional recovery following spinal cord injury (SCI) in mice. The key fi...
KEY FINDING: Double mutant mice (lacking both GFAP and Vimentin) exhibited significant recovery of locomotor function 5 weeks after spinal cord hemisection.
J Neurobiol, 2003 • January 8, 2003
This study examines the role of PDGF and FGF2 in regulating oligodendrocyte progenitor cell (OP) responses to demyelination using a murine hepatitis virus (MHV-A59) model in adult mice. The research d...
KEY FINDING: Endogenous PDGF and FGF2 stimulate the proliferation of OPs in cultures isolated during demyelination.
PNAS, 2002 • December 24, 2002
The study investigated the functional organization of somatosensory and motor cortex in an individual with a high cervical spinal cord injury and late recovery of function. fMRI results showed reorgan...
KEY FINDING: Vibratory stimulation of the hand did not activate the primary somatosensory cortex (SI) hand area.
Eur Spine J, 2003 • November 19, 2002
This case report describes a 48-year-old man with an intramedullary schwannoma extending from the conus medullaris to T11, causing bilateral lower extremity weakness. Gross total resection of the tumo...
KEY FINDING: Schwann cells can indeed invade the central nervous system, as demonstrated by the presence of an intramedullary schwannoma within the conus medullaris.