Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 12,021-12,030 of 12,052 results
TheScientificWorldJOURNAL, 2004 • July 20, 2004
This paper introduces an integrated care model designed to support individuals with severe life-changing injuries, particularly spinal cord injuries, in their journey toward regaining independence and...
KEY FINDING: The study emphasizes the importance of access to quality information and evidence-based resources to support informed decision-making for individuals recovering from severe life-changing injuries.
The Journal of Neuroscience, 2004 • July 14, 2004
This study demonstrates that a combinatorial approach, using cAMP to stimulate neuronal cell bodies and neurotrophin-3 (NT-3) to stimulate injured axons, can promote axonal regeneration beyond spinal ...
KEY FINDING: Combined delivery of cAMP and NT-3 significantly promoted axonal growth beyond the spinal cord lesion site, more so than either treatment alone.
PNAS, 2004 • June 8, 2004
This study demonstrates that rolipram, a phosphodiesterase inhibitor, can promote axonal regeneration and functional recovery after spinal cord injury in rats. Rolipram overcomes inhibitors of regener...
KEY FINDING: Rolipram overcomes inhibition by myelin in culture, promoting neurite outgrowth of DRG neurons.
The Journal of Neuroscience, 2004 • May 19, 2004
This study demonstrates that peripheral nerve injury leads to an increased expression of the Nav1.3 sodium channel in second-order spinal sensory neurons. The upregulation of Nav1.3 contributes to the...
KEY FINDING: Peripheral nerve injury upregulates the expression of Nav1.3 in dorsal horn nociceptive neurons, but not in astrocytes or microglia.
Spinal Cord, 2004 • May 1, 2004
This retrospective study examined the self-care, productivity, and leisure problems identified by individuals with SCI during rehabilitation, their satisfaction and performance levels, and the relatio...
KEY FINDING: Self-care goals were identified most frequently (79%) followed by productivity (12%) and leisure (9%) goals by individuals with SCI during rehabilitation.
Phil. Trans. R. Soc. Lond. B, 2004 • April 8, 2004
This study investigates the cellular and molecular mechanisms of regeneration in Xenopus tadpoles using transgenic methods and embryonic grafting. Key findings indicate that tail regeneration occurs w...
KEY FINDING: During tail regeneration in Xenopus tadpoles, there is no evidence of de-differentiation or metaplasia; instead, tissues regenerate from their corresponding tissues in the stump.
The Journal of Neuroscience, 2004 • March 24, 2004
The study reveals that DCC, a netrin-1 receptor, is present both on the neuronal surface and in intracellular pools in embryonic rat spinal commissural neurons. Netrin-1 application leads to a modest ...
KEY FINDING: Netrin-1 modestly increases cell surface DCC without activating PKA, suggesting a PKA-independent mechanism.
Spinal Cord, 2004 • March 1, 2004
This study examined the relationship between lower extremity muscle strength and walking performance in persons with chronic ISCI. Lower extremity muscle strength, in particular that of hip flexors, h...
KEY FINDING: Hip flexors, extensors, and abductors showed the highest correlations with functional walking measures on both sides of the body.
Clin Biomech (Bristol, Avon), 2004 • March 1, 2004
The purpose of this study was to estimate the loading environment for the distal femur during a novel standing exercise paradigm for people with spinal cord injury. A static, 2-D model was developed t...
KEY FINDING: Active-resistive stance resulted in maximal distal femur compression estimates of ~240% of body weight.
FASEB J., 2004 • February 1, 2004
This study demonstrates the potential of xenotransplantation of characterized OECs into the primate spinal cord, resulting in remyelination of demyelinated axons. The use of HT transgenic pig OECs, mo...
KEY FINDING: Transplantation of HT transgenic pig OECs into demyelinated lesions in the monkey spinal cord resulted in robust remyelination in 62.5% of transplant sites.