Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 12,041-12,050 of 12,052 results
The Journal of Cell Biology, 2002 • October 14, 2002
This study investigates the role of Nogo-A, a neurite growth inhibitor, in peripheral nerve regeneration by expressing it in Schwann cells of transgenic mice. The key finding is that Nogo-A expression...
KEY FINDING: Expression of Nogo-A in Schwann cells significantly delays axonal regeneration in the denervated adult mouse sciatic nerve.
International Orthopaedics (SICOT), 2002 • June 8, 2002
This study assessed pre-operative factors affecting the surgical results of expansive laminoplasty for cervical spondylotic myelopathy in 37 patients. The study found that pre-operative JOA score, Pav...
KEY FINDING: Patients with better pre-operative JOA scores, greater compression ratios, and larger Pavlov ratios had better surgical outcomes.
PNAS, 2002 • March 5, 2002
This study explores a novel approach to treating spinal cord injuries (SCI) by creating an implant that mimics the architecture of a healthy spinal cord. The implant consists of a polymer scaffold see...
KEY FINDING: Implantation of the scaffold-plus-cells promoted long-term improvement in function relative to a lesion-control group.
J Comp Neurol, 2002 • February 11, 2002
This study quantitatively assesses the remyelination potential of transplanted Schwann cells in demyelinated rat spinal cords, considering factors like donor age and cell preparation. The research dem...
KEY FINDING: Schwann cells, regardless of donor age or preparation method, can induce remyelination in spinal cord lesions.
J Orthop Sports Phys Ther, 2002 • February 1, 2002
Spinal cord injury induces significant adaptations in the muscular, skeletal, and neural systems. These adaptations can hinder rehabilitation efforts and future treatment options if not properly addre...
KEY FINDING: Paralyzed muscles transform to faster myosin types, increasing contractile speeds and fatigue.
PNAS, 2001 • December 18, 2001
This study investigates the effect of posttraumatic immunization with a peptide derived from Nogo-A (p472) on recovery from spinal cord injury in rats. The study found that immunization with p472 redu...
KEY FINDING: Posttraumatic immunization with p472, a peptide derived from Nogo-A, substantially reduced neuronal degeneration and promoted recovery after incomplete spinal-cord contusion in rats.
PNAS, 2001 • July 3, 2001
The study investigates the roles of BDNF and NT-4 in spinal cord sensory processing using knockout mice and an in vitro spinal cord preparation. Results show that BDNF, but not NT-4, is necessary for ...
KEY FINDING: BDNF-deficient mice showed reduced ventral root potential (VRP) evoked by stimulating nociceptive primary afferents, indicating impaired nociceptive transmission.
PNAS, 2001 • May 8, 2001
BMP2 alters the fate of CNS neural precursor cells from neurogenesis to astrocytogenesis. This alteration is mediated by negative HLH proteins. The findings have potential clinical applications for mi...
KEY FINDING: BMP2 reduces the number of cells expressing neuronal markers (MAP2) and markers for undifferentiated neural precursors (nestin).
Nat Biotechnol, 2000 • September 1, 2000
The study investigates the potential of xenotransplantation of genetically engineered pig cells, specifically olfactory ensheathing cells (OECs) and Schwann cells expressing the human complement inhib...
KEY FINDING: Transgenic pig OECs or Schwann cells transplantation restored impulse conduction across and beyond the lesion site in transected rat spinal cords.
PNAS, 2000 • July 5, 2000
The study investigates the physiological function of the kinin B1 receptor by generating mice with a targeted deletion of the B1 receptor gene. These mice are healthy and normotensive but show a blunt...
KEY FINDING: B1 receptor-deficient mice exhibited blunted hypotensive response to bacterial lipopolysaccharide.